Fabrication of polycaprolactone-cellulose acetate-poly(L-lactic acid) three-dimensional micro-nanofibrous porous scaffold composites and its bio-mineralization activity

ZHAO Jinyun; LIU Ruilai; HU Jiapeng; MU Jilin; FU Xingping

doi:10.13801/j.cnki.fhclxb.20210906.007

Volume 39 Issue 6

Jun. 2022

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ZHAO Jinyun, LIU Ruilai, HU Jiapeng, et al. Fabrication of polycaprolactone-cellulose acetate-poly(L-lactic acid) three-dimensional micro-nanofibrous porous scaffold composites and its bio-mineralization activity[J]. Acta Materiae Compositae Sinica, 2022, 39(6): 2918-2929. doi: 10.13801/j.cnki.fhclxb.20210906.007

Citation:

ZHAO Jinyun, LIU Ruilai, HU Jiapeng, et al. Fabrication of polycaprolactone-cellulose acetate-poly(L-lactic acid) three-dimensional micro-nanofibrous porous scaffold composites and its bio-mineralization activity[J]. Acta Materiae Compositae Sinica, 2022, 39(6): 2918-2929. doi: 10.13801/j.cnki.fhclxb.20210906.007

Citation:

ZHAO Jinyun, LIU Ruilai, HU Jiapeng, et al. Fabrication of polycaprolactone-cellulose acetate-poly(L-lactic acid) three-dimensional micro-nanofibrous porous scaffold composites and its bio-mineralization activity[J]. Acta Materiae Compositae Sinica, 2022, 39(6): 2918-2929. doi: 10.13801/j.cnki.fhclxb.20210906.007

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Fabrication of polycaprolactone-cellulose acetate-poly(L-lactic acid) three-dimensional micro-nanofibrous porous scaffold composites and its bio-mineralization activity

doi: 10.13801/j.cnki.fhclxb.20210906.007

ZHAO Jinyun^1
,,
LIU Ruilai^{1, 2},
HU Jiapeng^{1
,
,},
MU Jilin¹,
FU Xingping¹

1.
College of Ecological and Resources Engineering, Wuyi University, Wuyishan 354300, China
2.
College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China

Received Date: 2021-06-23
Accepted Date: 2021-08-14
Rev Recd Date: 2021-08-11

Available Online: 2021-09-07

Publish Date: 2022-06-01

Abstract

Abstract

3D nanofiber scaffold composites in bone tissue engineering are promising. Poly(L-lactic acid)-polycaprolactone-cellulose acetate 3D composite micro-nanofibrous porous scaffolds were prepared by low-temperature phase separation, without the assistance of additives. The effects of PCL-CA-PLLA ratio, quenching time, polymer concentration and quenching temperature on the morphology of fibrous scaffolds were investigated by SEM. The diameter of PCL-CA-PLLA (1∶1∶8) is (276±121) nm, which is similar to the size of the extracellular matrix (50-500 nm), and the porosity and specific surface area are 95.12% and 54.18 m²/g, respectively. It is indicated that PCL-CA-PLLA 3D micro-nanofibrous porous scaffold composites are 3D porous materials with high porosity and large specific surface area. Compared with pure PLLA fibrous scaffolds, the mechanical strength and hydrophilicity of PCL-CA-PLLA 3D micro-nanofibrous porous scaffold composites are improved. PLLA-PCL-CA 3D micro-nanofibrous are expected to be ideal tissue engineering scaffold materials.
- poly(L-lactic acid),
- cellulose acetate,
- polycaprolactone,
- micro-nanofibrous,
- scaffolds,
- bio-mineralization activity
Long Abstrsct
Innovation Points

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References(31)

References

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