The tungsten based composites, co-strengthened by La2O3and TiC with different contents, were prepared by the powder metallurgy method. The structure and mechanical properties at room temperature of La2O3-TiC/W composites were investigated. The results show that addition of La2O3 and TiC improves the mechanical properties of tungsten composites. The co-strengthening effect of La2O3 and TiC is better than that of La2O3 or TiC. Density and relative density of La2O3-TiC/W composites decrease with increasing the TiC content, which influences the hardness and elastic modulus of the composites. La2O3 with appropriate content is beneficial to improvement of relative density. The flexural strength has a maximum of 901MPa with composition of 1% La2O3-5% TiC/W, and fracture toughness has a maximum of 10.07 MPa·m1/2 with composition of 1% La2O3-10% TiC/W. In this experiment, the La2O3-TiC/W composite has optimal mechanical properties with addition of 1wt% La2O3and 5wt%TiC. The strengthening mechanisms of La2O3-TiC/W composite are fine grain strengthening and load transferring.The toughening mechanisms are fine grain toughening, crack deflection and microbridging.