Volume 40 Issue 10
Oct.  2023
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WANG Yixuan, QU Mengfei, ZHANG Hang, et al. Preparation and properties of oxidized hyaluronic acid-hydroxypropyl chitosan self-healing hydrogel[J]. Acta Materiae Compositae Sinica, 2023, 40(10): 5885-5892. doi: 10.13801/j.cnki.fhclxb.20230207.001
Citation: WANG Yixuan, QU Mengfei, ZHANG Hang, et al. Preparation and properties of oxidized hyaluronic acid-hydroxypropyl chitosan self-healing hydrogel[J]. Acta Materiae Compositae Sinica, 2023, 40(10): 5885-5892. doi: 10.13801/j.cnki.fhclxb.20230207.001

Preparation and properties of oxidized hyaluronic acid-hydroxypropyl chitosan self-healing hydrogel

doi: 10.13801/j.cnki.fhclxb.20230207.001
Funds:  Tianjin Key Laboratory of Marine Resources and Chemistry (201706); 2018 Tianjin Education Commission Scientific Research Program Project (2018KJ110); Tianjin Key Laboratory of Pulp and Paper Open Fund Project (201809)
  • Received Date: 2022-10-31
  • Accepted Date: 2023-01-18
  • Rev Recd Date: 2023-01-17
  • Available Online: 2023-02-08
  • Publish Date: 2023-10-15
  • In this paper, oxidized hyaluronic acid (OHA) was synthesized by oxidizing hydroxyl groups on hyaluronic acid (HA) with sodium periodate. OHA/HPCS self-healing hydrogel was prepared by using OHA and hydroxypropyl chitosan (HPCS) as raw materials. The aldehyde group on OHA reacted with the amino group of HPCS to form dynamic imine bond through Schiff base reaction. In this paper, the microscopic morphology and properties of OHA/HPCS self-healing hydrogel was characterized by FTIR, UV-vis, SEM, rheology and 1H NMR. OHA/HPCS hydrogels have a porous structure, and the results show that the pore size ranged from 70 to 200 μm by changing the amount of OHA. With the increase of the dosage of OHA, the pores in the OHA/HPCS hydrogels increase, the pore size becomes smaller, the swelling ratio of OHA/HPCS becomes smaller, and the degradation rate becomes slower. OHA/HPCS hydrogel can self-heal within 4 h at room temperature without external stimulation. OHA/HPCS hydrogel can release anticancer drug of gemcitabine in sustained way, with a cumulative release percent of 70%-84% in 12 days. OHA/HPCS hydrogels have the properties of sustained release gemcitabine, indicating that OHA/HPCS hydrogels have potential application prospects in the field of drug release.

     

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