Activated chlorine-modified zirconium-based MOF composites for efficient bacterial inhibition

In recent years, serious industrial pollution has led to the growth of various types of bacteria, and pathogenic bacterial infections can be spread rapidly by various means, posing a great risk of infection. Therefore, it is important to develop high-performance antibacterial materials and study their antibacterial mechanisms for application. To address this issue, we designed a novel nanocomposite bacteriostatic material UiO-66-NHCl by modifying zirconium-based metal-organic backbone material UiO-66-NH₂ via sodium chlorite solution, and characterized the structure and chemical composition of MOF composites by using XRD, FI-IR, SEM, TEM, EDS and XPS, and also explored the effect of different The effects of different loading processes on the chlorine loading were also explored, and the antibacterial properties and skin irritation experiments of UiO-66-NHCl composites were investigated. The results showed that the active chlorine was introduced on UiO-66-NH₂ by impregnation bonding, and the chlorine loading could be increased by changing the chlorine loading ratio (mUiO-66-NH₂∶mNaClO₂) and chlorination time of UiO-66-NH₂ in NaClO₂ solution, and the highest chlorine loading was achieved when the chlorine loading ratio was 1∶5 and the chlorination time was 4 h. Under the conditions of high temperature, high humidity and Under the conditions of high temperature, high humidity and strong light, it could still maintain 80% of its original chlorine loading and had good stability. The inhibition activity showed that the UiO-66-NHCl composites inhibited both S. aureus and E. coli compared to the original UiO-66-NH₂ material, and the samples with higher chlorine content showed higher inhibition effect and no irritation.