Preparation and drug loading property of magnetic ZnFe₂O₄-carboxymethyl chitosan composite microspheres

The magnetic ZnFe₂O₄ nanoparticles were prepared by sol-gel method, and the carboxymethyl chitosan(CMC) was obtained by modification of chitosan with water as the solvent. The ZnFe₂O₄ coated magnetic ZnFe₂O₄ -CMC composite microspheres were prepared with the crosslinker, in which the aspirin has been loaded. The materials were characterized by XRD, IR, SEM, TEM, VSM, UV, et al. The results show that the magnetic composite microspheres are well-shaped with the average diameter being about 1~5 μm, the saturation magnetization being 10.99 emu/g, the dose of releasing drug being 76.82% in 24 h, the loading rate being 0.801 g/g and the enveloping rate being 78.3%. The performance of material is excellent, which may be used as a novel drug carrier.