Research progress on the applications of gold nanoparticles@metal-organic framework composite nanozymes in biosensing and antitumor

Nanozymes derived from metal-organic frameworks (MOFs) are synthetic enzymes with adjustable porosity, high specific surface area, modifiable surfaces, and catalytic properties that emulate natural enzymes. Gold nanoparticles (AuNPs) modified MOFs (AuNPs@MOFs) composites form a significant category of MOFs-based nanozymes. Importantly, AuNPs exhibit a localized surface plasmon resonance effect, which can enhance the surface-enhanced Raman scattering (SERS) features of AuNPs@MOFs nanozymes and amplify their SERS signal intensity. Consequently, AuNPs@MOFs nanozymes have drawn increasing attention from researchers in recent years. This review focuses on the summarizing of the synthetic protocols of AuNPs@MOFs composites, their enzyme-like activities (such as peroxidase-like, oxidase-like and catalase-like), their advancements in bio-sensing and anticancer, and discussing their future prospects.