Preparation of self-healing oxidized sodium alginate-carboxymethyl chitosan hydrogel for sustained drug release

HOU Bingna; NI Kai; SHEN Huiling; LI Zhengzheng

doi:10.13801/j.cnki.fhclxb.20210518.005

Volume 39 Issue 1

Jan. 2022

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HOU Bingna, NI Kai, SHEN Huiling, et al. Preparation of self-healing oxidized sodium alginate-carboxymethyl chitosan hydrogel for sustained drug release[J]. Acta Materiae Compositae Sinica, 2022, 39(1): 250-257. doi: 10.13801/j.cnki.fhclxb.20210518.005

Citation:

HOU Bingna, NI Kai, SHEN Huiling, et al. Preparation of self-healing oxidized sodium alginate-carboxymethyl chitosan hydrogel for sustained drug release[J]. Acta Materiae Compositae Sinica, 2022, 39(1): 250-257. doi: 10.13801/j.cnki.fhclxb.20210518.005

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Preparation of self-healing oxidized sodium alginate-carboxymethyl chitosan hydrogel for sustained drug release

doi: 10.13801/j.cnki.fhclxb.20210518.005

School of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin 300457, China

Received Date: 2021-01-21
Accepted Date: 2021-05-11
Rev Recd Date: 2021-04-28

Available Online: 2021-05-18

Publish Date: 2022-01-15

Abstract

Abstract

The self-healing oxidized sodium alginate-carboxymethyl chitosan hydrogel (OSA-CMCS) was synthesized based on dynamic imine bonds. OSA was synthesized by oxidizing the uronic acid of sodium alginate, and self-healing OSA-CMCS hydrogels with different crosslinking degrees were prepared by Schiff base reaction with carboxymethyl chitosan, analyzed the microscopic morphology, viscoelastic properties, swelling properties, self-healing properties, enzymatic degradation properties and in vitro drug release properties of OSA-CMCS hydrogels. The results show that as the ratio of OSA to CMCS increase, the degree of crosslinking of the hydrogel gradually increase and the swelling ratio gradually decrease. OSA-CMCS hydrogel has the structural characteristics of highly porous and interconnected pores, and the pore size is in the range of 20-100 μm. At room temperature, OSA-CMCS hydrogel can realize self-healing within 6 hours without external stimulation. OSA-CMCS hydrogel is degradable, and as the degree of crosslinking increase, the degradation rate slow down. OSA-CMCS hydrogel has a slow-release effect on the water-soluble drug gemcitabine, and the drug release time can reach 4 days.
- self-healing,
- oxidized sodium alginate,
- carboxymethyl chitosan,
- hydrogel,
- sustained drug release
Long Abstrsct
Innovation Points

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References(28)

References

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