Shape memory properties and selective adsorption of drugs of multiple hydrogen-bondsreinforced hydrogels with vinyl diaminotriazine

PENG Xueyin; LI Xuefeng; LI Rongzhe; LI Jie; LONG Shijun; HUANG Yiwan

doi:10.13801/j.cnki.fhclxb.20200610.001

Volume 38 Issue 2

Feb. 2021

Turn off MathJax

Article Contents

Article Navigation > Acta Materiae Compositae Sinica > 2021 > 38(2): 470-478

PENG Xueyin, LI Xuefeng, LI Rongzhe, et al. Shape memory properties and selective adsorption of drugs of multiple hydrogen-bondsreinforced hydrogels with vinyl diaminotriazine[J]. Acta Materiae Compositae Sinica, 2021, 38(2): 470-478. doi: 10.13801/j.cnki.fhclxb.20200610.001

Citation:

PENG Xueyin, LI Xuefeng, LI Rongzhe, et al. Shape memory properties and selective adsorption of drugs of multiple hydrogen-bondsreinforced hydrogels with vinyl diaminotriazine[J]. Acta Materiae Compositae Sinica, 2021, 38(2): 470-478. doi: 10.13801/j.cnki.fhclxb.20200610.001

Citation:

PENG Xueyin, LI Xuefeng, LI Rongzhe, et al. Shape memory properties and selective adsorption of drugs of multiple hydrogen-bondsreinforced hydrogels with vinyl diaminotriazine[J]. Acta Materiae Compositae Sinica, 2021, 38(2): 470-478. doi: 10.13801/j.cnki.fhclxb.20200610.001

PDF( 1151 KB)

Shape memory properties and selective adsorption of drugs of multiple hydrogen-bondsreinforced hydrogels with vinyl diaminotriazine

doi: 10.13801/j.cnki.fhclxb.20200610.001

PENG Xueyin^1
,,
LI Xuefeng^{1, 2
,
,},
LI Rongzhe^1
,,
LI Jie^1
,,
LONG Shijun^{1, 2
,},
HUANG Yiwan^{1, 2
,}

1.
School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China
2.
Hubei Provincial Key Laboratory of Green Materials for Light Industry, Hubei University of Technology, Wuhan 430068, China

Received Date: 2020-04-07
Accepted Date: 2020-05-25

Available Online: 2020-06-10

Publish Date: 2021-02-15

Abstract

Abstract

The multiple H-bonds reinforced poly(acrylamide-co-2-vinyl-4,6-diamino-2-vinyl-1,3,5-triazine)/tannic acid (P(Am-co-VDT)/TA) hydrogels were prepared. Through testing and analysis of mechanical properties, micro-morphology and infrared spectrum, it's found that TA cross-linked the hydrogel through hydrogen bonding, making its structure more dense, and the hydrogel has high tensile strength (2.34 MPa) and elongation at break (410%). This is due to the formation of hydrogen-bond “soft” regions between the diaminotriazine (DAT) moieties on the polymer chains and the TA pyrogallol/catechol groups and a “hard” region of H-bonds forming by DAT moieties with itself. Such soft and hard dual-physically crosslinked networks dramatically enhance the mechanical properties of hydrogels in a synergistic manner. Due to the multiple hydrogen bonds, the hydrogel can rapidly response to shape memory within a few minutes. It can be quickly shaped and restored by changing the temperature, and the shape change can be maintained and repeated for many times. In addition, the hydrogels have capacity of physical adsorption of anti-inflammatory drug diclofenac sodium (DS) and other molecules with a specific spatially arranged chemical composition. This research will be of great significance in the fields of biomedicine, tissue engineering and medical materials.
- shape memory,
- diaminotriazine,
- high-strength hydrogels,
- multiple hydrogen-bonds,
- adsorption of drugs
Long Abstrsct
Innovation Points

FullText(HTML)

References(24)

References

[1]	GONG J P, KATSUYAMA Y, KUROKAWA T, et al. Double network hydrogels with extremely high mechanical strength[J]. Advanced Materials,2013,15(14):1155-1158.
[2]	LANED D, KAUR S, WEERASAKARE G M, et al. Toughened hydrogels inspired by aquatic caddiswormsilk[J]. Soft Matter,2015,11(35):6981-6990. doi: 10.1039/C5SM01297J
[3]	HU Y, DU Z, DENG X, et al. Dual Physically cross-linked hydrogels with high stretchability, toughness, and good self-recoverability[J]. Macromolecules,2016,49(15):5660-5669. doi: 10.1021/acs.macromol.6b00584
[4]	PRABAHARAN M, MANO J F. Stimuli-responsive hydrogels based on polysaccharides incorporated with thermo-responsive polymers as novel biomaterials[J]. Macromolecular Bioscience,2006,6(12):991-1008. doi: 10.1002/mabi.200600164
[5]	JEONG D, KIM H K, JEONG J P, et al. Cyclosophoraose/cellulose hydrogels as an efficient delivery system for galangin, a hydrophobic antibacterial drug[J]. Cellulose,2016,23(4):2609-2625. doi: 10.1007/s10570-016-0975-1
[6]	WAN G F, WEN Y, BAI T. The composite hydrogels of polyvinyl alcohol-gellangum-Ca²⁺ with improved network structure and mechanical property[J]. Materials Science and Engineering C,2016,69:268-275. doi: 10.1016/j.msec.2016.06.084
[7]	TANG L, LIU W, LIU G. High-strength hydrogels with integrated functions of H-bonding and thermoresponsive surface-mediated reverse transfection and cell detachment[J]. Advanced Materials,2010,22(24):2652-2656. doi: 10.1002/adma.200904016
[8]	胡亚薇. PVDAT@PS聚合物微球的合成及应用研究[D]. 武汉: 湖北工业大学, 2015. HU Y W. Synthesis and application of poly(VDAT)@polystyrenemicrospheres[D]. Wuhan: Hubei University of Technology, 2015(in Chinese).
[9]	TANG L, YANG Y, BAI T, et al. Robust MeO₂MA/vinyl-4,6-diamino-1,3,5-triazine copolymer hydrogels-mediated reverse gene transfection and thermo-induced cell detachment[J]. Biomaterials,2011,32:1943-1949. doi: 10.1016/j.biomaterials.2010.11.019
[10]	李荣哲, 李学锋, 龙世军, 等. 带氢键吸附功能高强度水凝胶的制备与性能[J]. 高分子材料科学与工程, 2019, 35(9):126-133. LI R Z, LI X F, LONG S J, et al. Preparation and properties of high strength hydrogels with hydrogen bond adsorption[J]. Polymer Materials Science & Engineering,2019,35(9):126-133(in Chinese).
[11]	XU B, LI Y, GAO F, et al. High strength multifunctional multiwalled hydrogel tubes: Ion-triggered shape memory, antibacterial, and anti-inflammatory efficacies[J]. ACS Applied Materials & Interfaces,2015,7(30):16865-16872.
[12]	LI X F, LI R Z, LIU Z F, et al. Integrated functional high-strength hydrogels with metal-coordination complexes and H-bonding dual physically cross-linked networks[J]. Macromolecular Rapid Communications,2018,39(23):1800400. doi: 10.1002/marc.201800400
[13]	HUANG L, WANG X T, XIE X, et al. Synthesis and DNA adsorption of poly(2-vinyl-4,6-diamino-1,3,5-triazine) coated polystyrene microspheres[J]. Journal of Wuhan University of Technology-Materials Science Edtion,2018,33(4):999-1006.
[14]	ASANUMA H, BAN T, GOTOH S, et al. Precise recognition of nucleotides and their derivatives through hydrogen bonding in water by poly(vinyldiaminotriazine)[J]. Supramolecular Science,1998,5:405-410.
[15]	李学锋. 二氨基三嗪官能团功能化纳米粒子及其制备和使用方法: 中国, CN103059493A[P]. 2013-04-24. LI X F. Preparation and instructions of diaminotriazine functional group functionalized nanoparticles: China, CN103059493A[P]. 2013-04-24(in Chinese).
[16]	XIE X, HUANG L, LIU Z, et al. Synthesis of poly(2-vinyl-4,6-diamino-1,3,5-triazine) nanoparticles by semicontinuous precipitation polymerization, characterization and application to bovine hemoglobin adsorption[J]. Reactive & Functional Polymers,2019,141:58-67.
[17]	FAN H, WANG J, JIN Z. Tough, swelling-resistant, self-healing, and adhesive dual-cross-linked hydrogels based on polymer-tannic acid multiple hydrogen bonds[J]. Macromolecules,2018,51:1696-1705. doi: 10.1021/acs.macromol.7b02653
[18]	CHEN Y N, PENG L, LIU T, et al. Poly(vinyl alcohol)-tannic acid hydrogels with excellent mechanical properties and shape memory behaviors[J]. ACS Applied Materials & Interfaces,2016,8:27199-27206.
[19]	FENG Z, ZUO H, GAO W, et al. A robust, self-healable, and shape memory supramolecular hydrogel by multiple H-bondsing interactions[J]. Macromolecular Rapid Communications,2019,39(20):1800138.
[20]	FAN H L, WANG L, FENG X D, et al. Supramolecular hydrogel formation based on tannic acid[J]. Macromolecules,2017,50(2):666-676. doi: 10.1021/acs.macromol.6b02106
[21]	FAN H L, WANG J H, ZHANG Q Y, et al. Tannic acid-based multifunctional hydrogels with facile adjustable adhesion and cohesion contributed by polyphenol supramolecular chemistry[J]. ACS Omega,2017,2(10):6668-6676. doi: 10.1021/acsomega.7b01067
[22]	ZHENG L, SHI J, CHI Y, et al. Tannic acid physically cross-linked responsive hydrogel[J]. Macromolecular Chemistry and Physics,2018,219:1800234. doi: 10.1002/macp.201800234
[23]	LIU B, WANG Y, MIAO Y, et al. Hydrogen bonds autonomously powered gelatin methacrylate hydrogels with super-elasticity, self-heal and underwater self-adhesion for sutureless skin and stomach surgery and E-skin[J]. Biomaterials,2018,171:83-96. doi: 10.1016/j.biomaterials.2018.04.023
[24]	ZHANG X N, WANG Y J, SUN S, et al. A tough and stiff hydrogel with tunable water content and mechanical properties based on the synergistic effect of hydrogen bonding and hydrophobic interaction[J]. Macromolecules,2018,51(20):8136-8146. doi: 10.1021/acs.macromol.8b01496