Local connection pull-out failure of composite foam sandwich plate were experimentally studied, the failure mode failure load and the influence of panel on joint were analyzed. Numerical analysis was carried out by using ABAQUS finite element software. Simulation results verified the reliability of the model by comparing with the experimental results, The failure mode and internal structure parameters influence on joint destruction were prognosticated and analyzed. The progressive failure in the foam core and the debonding of the adhesive layer between the panel and the foam core were studied. The results show that the crack is generated on the edge foam of foam sandwich plate pre-buried bolt connection structure sealant, and extends to the middle part. When the middle region is all cracked, the cracks at the two ends extend upward along the direction of 45°. The cracking area of the adhesive layer is curved in a shape of curved strip, distributes on both sides of the bolt fastener, and in the width direction of the panel, the cracked area runs through both sides. When maximum depth of embedded parts increases, failure load is also increased. Subcritical failure load and maximum failure load do not change obviously when diameters of embedded parts increase, but the biggest failure displacement reduces.