Preparation and characterization of nano β-tricalcium phosphate-collagen/chondroitin sulfate scaffold composites

XUE Yuan; DAN Nianhua; DAN Weihua

doi:10.13801/j.cnki.fhclxb.20160906.002

Volume 34 Issue 4

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XUE Yuan, DAN Nianhua, DAN Weihua. Preparation and characterization of nano β-tricalcium phosphate-collagen/chondroitin sulfate scaffold composites[J]. Acta Materiae Compositae Sinica, 2017, 34(4): 881-889. doi: 10.13801/j.cnki.fhclxb.20160906.002

Citation:

XUE Yuan, DAN Nianhua, DAN Weihua. Preparation and characterization of nano β-tricalcium phosphate-collagen/chondroitin sulfate scaffold composites[J]. Acta Materiae Compositae Sinica, 2017, 34(4): 881-889. doi: 10.13801/j.cnki.fhclxb.20160906.002

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Preparation and characterization of nano β-tricalcium phosphate-collagen/chondroitin sulfate scaffold composites

doi: 10.13801/j.cnki.fhclxb.20160906.002

XUE Yuan^1,2,
DAN Nianhua^1,2,
DAN Weihua^{1,2
,}

1.
National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China;
2.
Biomedical Engineering Technology Research Center, Sichuan University, Chengdu 610065, China

Received Date: 2016-05-19
Rev Recd Date: 2016-07-31
Publish Date: 2017-04-15

Abstract

Abstract

Based on the theory of bionics, nano β-tricalcium phosphate-collagen/chondroitin sulfate (nano β-TCP-Col/CS) scaffold composites were modified by dehydrathermal (DHT) and 1-Ethyl-3-(3-Dimethylaminopropyl) (EDC) using nano β-tricalcium phosphate(nano β-TCP), collagen(Col) and chondroitin sulfate(CS) as the raw materials. The structure and properties of nano β-TCP-Col/CS scaffold composites were investigated by XRD, AFM, SEM, XPS, TG and degradation and mineralization in simulated body fluid (SBF). The results indicate that the size of β-TCP is 41.3nm. Due to a strong interaction among nano β-TCP, Col and CS, nano β-TCP-Col/CS scaffold composites has strong stability, mineralized biological activity and appropriate biodegradability, which is a kind of potential dental restorative materials.
- bionics,
- nano structure,
- scaffold composites,
- β-tricalcium phosphate,
- collagen
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