Abstract: The delamination damage has significant influence on the bearing capacity and failure mode of open-hole laminates. By combining experiment and simulation, the compression bearing capacity and failure mode of composite open-hole laminates with single prefabricated laminated defects, two laminated coupling defects on the same side and double laminated coupling defects on the different side were studied. Through the embedded polytetrafluoroethylene (PTFE) membrane, the open-hole laminate containing single prefabricated delamination defects was prepared. By means of immersion ultrasonic C scan and digital image DIC technique, the damage evolution and normal deformation were characterized and monitored. The delamination propagation behavior and failure deformation characteristics of laminates with various defect sizes under compression loading were studied, and the influence mechanism of the size of the delamination defects on the bearing capacity of the laminates was revealed. A numerical model of open-hole laminate was established based on the cohesion element method. The damage propagation mechanism of open-hoe laminate with single prefabricated laminated defects was explored. Based on the optimized model, the numerical prediction and analysis of the buckling deformation, delamination expansion and bearing capacity of the open-hole laminate with two delaminated coupling defects were carried out. The experimental results show that the specimen with single delamination defect presents the initial compression, local buckling and overall buckling. The delamination size has significant impact on the compressive capability, which decreases with the increasing of delamination size. The numerical results of two delaminated defects show the second delaminated defect further reduces the compressive bearing capacity. The failure model of laminate with two coupling defects on the same sides is similar with that of laminates with single prefabricated defect; while, double-crack propagation occurs in the asymmetrical coupled laminated structure on the opposite side, which further weakens the compression bearing capacity of open-hole laminates.