Abstract: The sodium stearate-tetra-needle-like zinc oxide whiskers (T-ZnOw)/natural rubber (NR) antibacterial medical composites were prepared by introducing the sodium stearate-T-ZnOw ultrasonic dispersion into natural rubber latex (NRL) matrix. The comprehensive mechanical properties, antibacterial properties and thermal stability properties of the composites were systematically studied. The results show that when sodium stearate-T-ZnOw loading of 3wt%, the mechanical properties and thermal stability properties of the composites achieve optimum results. Compared with the pure NR, the shore a hardness, modulus at 300%, tensile strength, tear strength and elongation at break of composites are increased by 8.6%, 25.4%, 20.3%, 25.6% and 6.4%, respectively; The initial thermal degradation temperature (T₀) and the termination thermal degradation temperature (T_f) of the composites are increased by 21.2℃ and 5.9℃. When the content of sodium stearate-T-ZnOw exceeds 3wt%, it can inhibit the growth of Escherichia coli, Staphylococcus aureus, Acinetobacter baumannii and Staphylococcus epidermidis in natural rubber latex. It can enter bacterial cells, resulting in cell wall damage, cell leakage, cell death.