Abstract: Biomimetic superhydrophobic surfaces have been widely used in critical areas such as healthcare, environment, and energy. First, this work briefly reviewed bioinspired design and preparation technology, which combined with theoretical basis on superhydrophobicity. Second, due to the significant biological effects for high water/blood-repellency, biological/blood compatibility, anticoagulation/thrombosis, anti-bacteria, low bio-adhesion, etc., superhydrophobic surfaces have attracted much attention in biomedical applications. The present work mainly focused on summarizing representative applications of bioinspired superhydrophobic surfaces in wound healing (hemostatic dressings), anti-coagulation/anti-thrombotic (blood-contact medical devices), antibacterial surfaces, drug release, motion monitoring, biochips, anticorrosion of magnesium alloy, biomedical detection and so on in recent years. Finally, combining with our own research experience, we deeply analyzed the existing issues and challenges of bioinspired superhydrophobic surfaces in practical biomedical applications, mainly involving mechanical durability, chemical corrosion, biofouling, interfacial construction, and biomedical applications. Therefore, focusing on practical functions and high performance, conceptual design of superhydrophobic surfaces will be moved toward industrial applications.