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纳米金刚石/酵母-壳聚糖复合微球的制备及光热控释性能

王锦 白波 罗钰 葛广宁 邓祥云 王其召 曹芳利

王锦, 白波, 罗钰, 等. 纳米金刚石/酵母-壳聚糖复合微球的制备及光热控释性能[J]. 复合材料学报, 2022, 40(0): 1-10
引用本文: 王锦, 白波, 罗钰, 等. 纳米金刚石/酵母-壳聚糖复合微球的制备及光热控释性能[J]. 复合材料学报, 2022, 40(0): 1-10
Jin WANG, Bo BAI, Yu LUO, Guangning GE, Xiangyun DENG, Qizhao WANG, Fangli CAO. Preparation and photo-thermal controlled release properties of nanodiamond/yeast-chitosan composite microspheres[J]. Acta Materiae Compositae Sinica.
Citation: Jin WANG, Bo BAI, Yu LUO, Guangning GE, Xiangyun DENG, Qizhao WANG, Fangli CAO. Preparation and photo-thermal controlled release properties of nanodiamond/yeast-chitosan composite microspheres[J]. Acta Materiae Compositae Sinica.

纳米金刚石/酵母-壳聚糖复合微球的制备及光热控释性能

基金项目: 陕西省科技计划项目重点研发计划(No. 211429220192);陕西省自然科学基础研究计划资助项目(项目编号No. 2021 SF-497和No. 2022 TD-04);陕西省水利科技项目(2015 slkj-02),中央高校基本科研专项(CHD300102291403,CHD300102290103和CHD300102292903);长安大学2021年大学生创新创业训练计划专项(S202110710308);
详细信息
    通讯作者:

    罗钰,硕士研究生导师,主要从事新型复合材料制备及应用方面的研究工作 E-mail:13289367808@163.com

  • 中图分类号: TB332

Preparation and photo-thermal controlled release properties of nanodiamond/yeast-chitosan composite microspheres

Funds: Shaanxi Provincial Key Research and Development Program of Science and Technology (No.211429220192); Natural Science Basic Research Program of Shaanxi Province (No.2021 SF-497 and No.2022 TD-04); Water Conservancy Science and Technology Project of Shaanxi Province, No.2015 SLKJ-02, Basic Research Project of The Central Universities, No.CHD300102291403, CHD300102290103 and CHD300102292903; Chang 'an University Innovation and Entrepreneurship Training Program for College Students in 2021 (S202110710308).
  • 摘要: 开发高性能功能性光热凝胶并建立药物控释模型对农药智能输送材料的开发具有重要意义。以酵母-壳聚糖水凝胶(YS-CS)为基体,引入光热材料纳米金刚石(DND),通过碱凝胶法合成了纳米金刚石/酵母-壳聚糖(DND/YS-CS)交联网络结构复合凝胶微球,研究了复合微球的微观结构、力学性能和光热转换性能;以吲哚丁酸(IBA)为模型药物,探讨DND/YS-CS对IBA的负载性能和控释性能,揭示复合微球对IBA的光热控释机制。结果表明,复合微球具有良好的力学性能,在分别超声和离心1 h后,DND含量为2.0 mg/mL复合微球保水能力分别达到70.5%和74%;复合微球具有良好的光热转换能力,一个太阳光强度下,最高温度可达37.6℃;DND含量为1.2 mg/mL复合微球对IBA的吸附量最高,可达到41.73 μg/mg;微球在光下药物释放模式符合Korsmeyer-Peppas模型,在光下具有明显的刺激响应行为,药物释放呈现“开-关”模式。通过控制光的照射强度控制药物释放,在农业领域有广阔的应用前景。

     

  • 图  1  纳米金刚石/酵母-壳聚糖(DND/YS-CS)微球的形成及吲哚丁酸(IBA)释放过程示意图

    Figure  1.  Schematic illustration of the synthesis of nanodiamond/yeast-chitosan (DND/YS-CS) composite microspheres and indole-3-butyric acid (IBA) release process

    图  2  YS、CS、DND和DND/YS-CS的FT-IR图

    Figure  2.  FT-IR spectra of YS, CS, DND and DND/YS-CS

    图  3  (a, b, d)分别为DND、CS、YS照片;(c)为DND的TEM图;(e)溶胀平衡的复合材料(湿)和干燥后的复合材料(干)照片;(f, g)和(h, i)分别为CS、DND/YS-CS的SEM图;(j, k)分别为YS-CS、DND/YS-CS的截面以及相应的元素分布图

    Figure  3.  (a, b, d) DND, CS, and YS photos , respectively; (c) TEM images of DND; (e) Photographs of dissolution equilibrium composite (wet) and dried composite (dry); (f, g) and (h, i) SEM images of CS, DND/YS-CS, respectively; (j, k) are the cross sections of YS-CS, DND/YS-CS and the corresponding elemental distributions, respectively

    图  4  DND/YS-CS:(a)4000 r/min离心,(b)40 kHz超声,(c)力学强度分析

    Figure  4.  DND/YS-CS: (a) 4000 r/min centrifugation and; (b) 40 kHz ultrasonication; (c) mechanical strength analysis

    图  5  (a)DND、YS-CS和DND/YS-CS的紫外可见漫反射光谱图;(b)纯水和1.2 mg/mL DND溶液的温度变化图; 100 mW/cm2下不同DND含量DND/YS-CS复合微球的红外热成像图(c)以及相应的温度随时间变化图(d)

    Figure  5.  (a) UV-vis diffuse reflectance spectra of DND, YS-CS and DND/YS-CS; (b) temperature variation of pure water and 1.2 mg/mL DND solution; Infrared thermal imaging (c) of DND/YS-CS microspheres with different contents of DND under irradiation 100 mW/cm2 and the corresponding temperature variation (d)

    图  6  不同含量DND复合微球对IBA的负载量

    Figure  6.  IBA loading rates of DND composite microspheres with different contents of DND

    图  7  (a)不同含量DND复合微球在光下的IBA释放及其相对应的模型:(b)一级模型;(c)Korsmeyer-Peppas模型;(d)Higuchi模型

    Figure  7.  (a) IBA release from DND/YS-CS composite microspheres with different contents of DND under light and their corresponding models: (b) Primary model; (c) Korsmeyer-Peppas model; (d) Higuchi model

    Mt, M∞—Cumulative amount of drug released at time t and equilibrium, respectively (μg/mL)

    图  8  ND/YS-CS复合微球(DND含量1.2 mg/mL)间歇光照及无光照条件下IBA的释放(a)D以及相对应的温度变化(b)

    Figure  8.  IBA release (a) from DND/YS-CS composite microsphere (1.2 mg/mL DND) with intermittent light and without light and the corresponding temperature change (b)

    表  1  不同动力学模型相对应的参数

    Table  1.   Parameters corresponding to different dynamics models

    Sample/
    (mg·mL−1)
    Primary modelKorsmeyer-Peppas modelHiguchi model
    KR2KR2nKR2
    00.03530.83262.55920.94540.467711.1290.9436
    0.40.06000.788940.18520.94740.558011.4900.9135
    0.80.06230.804525.08820.94910.534613.1460.9278
    1.20.06540.779946.91320.92580.524114.1430.8676
    2.00.06250.764746.07170.92970.534713.1730.8880
    Notes:K—release kinetic constant;n—the diffusional exponent characteristic to describe the release mechanism;R2—coefficient of association
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  • 收稿日期:  2022-04-27
  • 录用日期:  2022-06-03
  • 修回日期:  2022-05-17
  • 网络出版日期:  2022-06-18

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