纳米羟基磷灰石/聚碳酸酯复合生物材料Ⅱ:体外生物活性
详细信息Nano-hydroxyapatite/polycarbonate composites Ⅱ: Bioactivity in vitro
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摘要: 研究了纳米羟基磷灰石/聚碳酸酯(n-HA/ PC)生物复合材料在模拟体液(SBF)中的表面变化,并用傅里叶红外光谱(FTIR) 、X射线衍射仪(XRD)和扫描电子显微镜(SEM)对材料的表面变化进行了分析。结果表明,n-HA/PC生物复合材料在模拟体液(SBF)中浸泡后,表面会沉积碳酸化羟基磷灰石(CHA),随着浸泡时间的延长,沉积层变厚,CHA晶体形貌变得规整。对n-HA/PC复合材料进行了细胞实验，通过四唑盐(MTT)检测和扫描电镜观察,表明n-HA/PC复合材料无细胞毒性,细胞形态正常,是一种有应用前景的可承力骨修复替代材料。Abstract: The in vitro bioactivity of nano-hydroxyapatite/polycarbonate (n-HA/PC) composite was studied in SBF (simulated body fluid) . The sample surface was characterized by FTIR , XRD and SEM. The results show that n-HA/ PC composite is chemically active in SBF , and the Ca and P ions of carbonated-apatite (CHA) deposit on the surface during soaking in SBF. The Ca-P precipitate on the surface of n-HA/PC composite was CHA. The layer of deposited CHA increases with time , and the morphology of CHA crystal gradually forms. By MTT and SEM analyses , the results show that n-HA/PC composite is not cell toxic and has a good biocompatibility to MG-63 cells.Therefore , this kind of composite could be one of the best potential bioactive materials for the load bearing bone substitute.
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Keywords:
- nano2hydroxyapatite /
- polycarbonate /
- composites /
- simulated body fluid /
- bioactivity
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