Abstract: With the development of nuclear energy, the radionuclide uranium flows into the environment through various channels, posing a potential threat to human health. Using waste corn stalks as raw materials, self-made corn stalk starch (CSS) was used, and magnetic γ-Fe₂O₃ was wrapped on the surface of CSS by co-precipitation method to synthesize magnetic γ-Fe₂O₃/CSS, which was used to adsorb U(VI) in the solution. The effects of factors such as initial pH value, dosage, time, initial concentration, temperature and coexisting ions on the adsorption performance of γ-Fe₂O₃/CSS for U(VI) were investigated and analyzed. The SEM, FTIR, XPS were used to characterize and analyze the magnetic γ-Fe₂O₃/CSS before and after adsorption, and the technical mechanism of adsorption of U(VI) was deeply studied. The results show that the maximum adsorption capacity of γ-Fe₂O₃/CSS for U(VI) reaches 214.1 mg/g in certain conditions. The quasi-second-order kinetic model describes the adsorption process more accurately, that is, chemical adsorption is the main. The adsorption of magnetic γ-Fe₂O₃/CSS on U(VI) satisfies Langmuir model and Freundlich model. The adsorption mechanism is mainly complex reaction and ion exchange between U(VI) and the hydroxyl and carboxyl groups of γ-Fe₂O₃/CSS. Four adsorption and desorption experiments show that the U(VI) adsorption rate is still above 78.60%, indicating that the magnetic γ-Fe₂O₃/CSS has a certain regeneration ability.