壳聚糖/氧化石墨烯复合材料研究现状

莫丽娟; 刘莹; 张靖羚; 王子豪

壳聚糖/氧化石墨烯复合材料研究现状

1.
辽宁工程技术大学　材料科学与工程学院, 阜新 123000
2.
辽宁工程技术大学　理学院, 阜新 123000

详细信息

通讯作者:
刘莹，硕士，教授，硕士生导师，研究方向为生物功能材料　E-mail: liuyingfx02@126.com

中图分类号: R318.08; TB332
计量
- 文章访问数: 81
- HTML全文浏览量: 22
- 被引次数: 0
出版历程
- 收稿日期: 2024-05-27
- 修回日期: 2024-07-25
- 录用日期: 2024-08-04
- 网络出版日期: 2024-08-19

Research status of chitosan/graphene oxide composites

1.
College of Materials Science and Engineering, Liaoning Technical University, Fuxin 123000, China
2.
College of Science, Liaoning Technical University, Fuxin 123000, China

摘要

摘要: 壳聚糖(CS)是具有良好生物相容性、可生物降解、无毒、抗菌等优点的天然碱性多糖，但CS材料力学性能较差、遇水易水解。氧化石墨烯(GO)具有较大的比表面积和良好的生物相容性、稳定性，能与其他材料结合制备出性能更优异的复合材料。将CS与GO进行复合，实现优势互补，可以得到兼具优异力学性能、生物活性和生物相容性的壳聚糖/氧化石墨烯(CS/GO)复合材料，CS/GO复合材料可以制备成水凝胶、纳米颗粒、薄膜、多孔材料等形式，这使CS/GO复合材料在环保、食品、医用等领域具有良好的应用前景。本文综述了CS/GO复合材料在药物载体、伤口敷料、组织工程支架、污染物吸附、食品保鲜五个方面的研究现状，并对CS/GO复合材料未来研究方向进行展望。
- 壳聚糖 /
- 氧化石墨烯 /
- 药物载体 /
- 伤口敷料 /
- 组织工程支架 /
- 吸附 /
- 食品保鲜
Abstract: Chitosan (CS) is a natural alkaline polysaccharide with good biocompatibility, biodegradable, non-toxic, antibacterial and other advantages, but CS material has poor mechanical properties and easy hydrolysis in water. Graphene oxide (GO) has a large specific surface area and good biocompatibility, stability, and can be combined with other materials to prepare more excellent properties of composite materials. By combining CS and GO to achieve complementary advantages, chitosan/graphene oxide(CS/GO) composites with excellent mechanical properties, biological activity and biocompatibility can be obtained, CS/GO composites can be prepared into hydrogels, nanoparticles, films, porous materials and other forms, which makes CS/GO composites have good application prospects in environmental protection, food, medical and other fields. In this paper, the research status of CS/GO composites in drug carrier, wound dressing, tissue engineering scaffold, contaminant adsorption, food preservation was reviewed, and the future research direction of CS/GO composites was prospected.
- chitosan /
- graphene oxide /
- drug carrier /
- wound dressing /
- tissue engineering scaffold /
- adsorption /
- food preservation

HTML全文

图 1 甲壳素与壳聚糖(CS)化学结构示意图和氧化石墨烯(GO)结构示意图

Figure 1. Schematic Chemical Structure of Chitin and Chitosan (CS) and Schematic Structure of Graphene Oxide (GO)

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图 2 CS/GO复合材料的应用及优势

Figure 2. Application and characteristics of CS/GO composites

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图 3 CS/GO合成示意图

Figure 3. Schematic diagram of CS/GO oxide synthesis

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图 4 不同形式CS/GO复合材料的扫描电镜图：(a)水凝胶^[27]；(b)纳米颗粒^[28]；(c)薄膜^[29]；(d)多孔材料^[30]

Figure 4. SEM images of different CS/GO composites：(a)Hydrogel^[27]；(b) Nanometer particle^[28]；(c)Thin film^[29]；(d)Porous material^[30]

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图 5 CS/GO负载甲硝唑药物的制备步骤^[34]

Figure 5. Preparation steps of metronidazole drugs loaded with CS/GO^[34]

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图 6 神经元在CS/GO支架中的迁移^[45]

Figure 6. Neuron migration in the CS/GO scaffold^[45]

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表 1 CS/GO复合材料对不同药物的释放效果^[34]

Table 1. Release efficacy of CS/GO composites on different drugs^[34]

Carrier material	Carrier format	Drug	Release time/h
CS/GO	Gel	Ibuprofen	100
	Gel	Sumatriptan	50
	Thin film	Camptothecin	72
	Thin film	Famotidine	12
	Nanometer particle	Metronidazole	84
	Nanometer particle	Folic acid	72

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