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3D打印可定制热塑性聚氨酯/聚已内酯共混物食管支架的生物力学性能

韦归鸿 武贵林 曾帅 黄圣华 张麒麟 冯军 曾博 于鹏

韦归鸿, 武贵林, 曾帅, 等. 3D打印可定制热塑性聚氨酯/聚已内酯共混物食管支架的生物力学性能[J]. 复合材料学报, 2024, 42(0): 1-10.
引用本文: 韦归鸿, 武贵林, 曾帅, 等. 3D打印可定制热塑性聚氨酯/聚已内酯共混物食管支架的生物力学性能[J]. 复合材料学报, 2024, 42(0): 1-10.
WEI Guihong, WU Guilin, ZENG Shuai, et al. Biomechanical properties of a customizable thermoplastic polyurethane/ polycaprolactone blended esophageal stent fabricated by 3D printing[J]. Acta Materiae Compositae Sinica.
Citation: WEI Guihong, WU Guilin, ZENG Shuai, et al. Biomechanical properties of a customizable thermoplastic polyurethane/ polycaprolactone blended esophageal stent fabricated by 3D printing[J]. Acta Materiae Compositae Sinica.

3D打印可定制热塑性聚氨酯/聚已内酯共混物食管支架的生物力学性能

基金项目: 广西南宁市技术创新引导专项项目(20204122);广西高校引进海外高层次人才“百人计划”项目
详细信息
    通讯作者:

    于鹏,博士,副教授,硕士生导师,研究方向为材料力学、结构抗冲击力学 E-mail: py@gxu.edu.cn

  • 中图分类号: R318.01;TB324;TB332

Biomechanical properties of a customizable thermoplastic polyurethane/ polycaprolactone blended esophageal stent fabricated by 3D printing

Funds: Guangxi Nanning Technology Innovation Guidance Project (20204122); Guangxi universities to introduce overseas high-level talents "100 people plan" project
  • 摘要: 食管支架在食管疾病的临床治疗中有广泛的应用。但商业食管支架尺寸固定,无法根据患者食管的几何形状进行个性化定制。通过熔融共混结合3D打印技术的方式制备了一种热塑性聚氨酯(TPU)/聚己内酯(PCL)共混物食管支架,并基于对TPU/PCL组分比例的调节,实现了对支架力学性能的调控。通过差示扫描量热、热重分析、力学试验、体外降解试验和细胞毒性检测研究了TPU/PCL共混物的理化特性及支架的各项关键指标。结果表明,TPU/PCL共混物具有良好的材料相容性和力学性能,且细胞活性为72.9%,对细胞无潜在毒性。经过为期8周的体外降解试验,支架的重量损失均小于2%,且力学性能无明显变化。3D打印TPU/PCL共混物支架优越的力学和生物学性能证明了其在食管狭窄的临床个性化治疗中具有潜在应用前景。

     

  • 图  1  双螺杆挤出机和3D打印制备热塑性聚氨酯(TPU)/聚已内酯(PCL)共混物食管支架的示意图

    Figure  1.  Schematic illustration of thermoplastic polyurethane (TPU)/polycaprolactone (PCL) blends preparation using a twin-screw extruder and 3D printing for esophageal stent

    图  2  3D打印TPU/PCL共混物食管支架试验

    Figure  2.  3D printed TPU/PCL blended esophageal stent test

    图  3  食管支架结构

    Figure  3.  Esophageal stent structure

    图  4  5种不同组分比的TPU/PCL共混物支架(从左到右依次为:PCL;60TPU/40PCL;70TPU/30PCL;80TPU/20PCL;TPU)

    Figure  4.  Five kinds of TPU/PCL blended stents with different component ratios (From left to right: PCL, 60TPU/40PCL, 70TPU/30PCL, 80TPU/20PCL, TPU)

    图  5  不同组分比TPU/PCL共混物的热重分析法(TGA)热图

    Figure  5.  Thermogravimetric analysis (TGA) thermograms of TPU/PCL blends with different component ratios

    图  6  不同组分比TPU/PCL共混物的差示扫描量热测试(DSC)曲线

    Figure  6.  Differential scanning calorimetry (DSC) curves of TPU/PCL blends with different component ratios

    图  7  不同组分比TPU/PCL共混物的拉伸性能

    Figure  7.  Tensile properties of TPU/PCL blends with different component ratios

    图  8  不同组分比TPU/PCL共混物的极限拉伸强度和拉伸模量

    Figure  8.  Ultimate tensile strength and modulus of TPU/PCL blends with different component ratios

    图  9  不同组分比TPU/PCL共混物支架和商业食管支架的径向力-位移曲线

    Figure  9.  Radial force-distance curves of stents with different component ratios of TPU/PCL blends and commercial esophageal stents

    图  10  不同组分比TPU/PCL共混物支架的抗迁移力

    Figure  10.  Migration resistance force of TPU/PCL blended stents

    图  11  不同组分比TPU/PCL共混物支架在模拟胃液(SGF)和磷酸盐缓冲液(PBS)中降解8周后的重量和径向力变化

    Figure  11.  Weight and radial force changes of TPU/PCL blended stents with different component ratios after 8 weeks of degradation in Simulated gastric fluid (SGF) and Phosphate buffer saline (PBS)

    图  12  显微镜下各组的L-929细胞的细胞形态

    Figure  12.  Cell morphology of L-929 cells in each group under the microscope

    表  1  不同组分比TPU/PCL共混物的打印参数

    Table  1.   Printing parameters of TPU/PCL blends with different component ratios

    Sample Nozzle
    temperature/℃
    Build plate
    temperature /℃
    TPU 210 50
    80TPU/20PCL 210 35
    70TPU/30PCL 210 35
    60TPU/40PCL 210 35
    PCL 100 35
    Notes: Printing speed: 20 mm/s. Layer height: 0.1 mm.
    下载: 导出CSV

    表  2  不同组分比TPU/PCL共混物的弯曲力学性能

    Table  2.   Flexural mechanical properties of TPU/PCL blends with different component ratios

    Sample Flexural modulus/MPa Flexural strength/MPa Maximal force/N
    TPU 9.0±0.27 0.8±0.01 1.2±0.03
    80TPU/20PCL 23.7±0.47 1.6±0.05 3.1±0.22
    70TPU/30PCL 42.0±0.00 2.3±0.04 3.8±0.06
    60TPU/40PCL 62.0±4.08 3.0±0.04 5.0±0.07
    PCL 416.7±4.72 13.9±0.03 23.1±0.05
    下载: 导出CSV
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出版历程
  • 收稿日期:  2024-02-27
  • 修回日期:  2024-04-27
  • 录用日期:  2024-05-13
  • 网络出版日期:  2024-06-13

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