Preparation and properties of sulfadiazine Ag/polyvinyl alcohol hydrogel composites
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摘要: 采用e-Beam电子辐射和冻融循环相结合的方法制备了磺胺嘧啶银（SD-Ag）/聚乙烯醇（PVA）水凝胶。研究了制备工艺对PVA水凝胶的性能的影响。通过拉伸性能测试、吸水率检测、SEM和FT-IR等表征，考察了PVA浓度（占总质量5%~15%）、冻融与辐射处理等对PVA水凝胶拉伸强度、断裂伸长率、吸水性、凝胶含量和微观结构等的影响。结果表明：随着PVA浓度增大，PVA水凝胶的拉伸强度提高。当PVA浓度为15%、辐射剂量为25 kGy时，单独辐射、辐射后冻融及冻融后辐射三种工艺制备的PVA水凝胶拉伸强度分别为0.023 MPa、0.048 MPa、0.028 MPa，吸水率分别为为95%、45%、63%，说明经冻融处理的水凝胶力学强度提高，吸水率有所下降。然后，选择适当的制备工艺并在PVA水凝胶中加入SD-Ag，考察了SD-Ag/PVA水凝胶的抑菌性能，抑菌活性测试结果显示，随着SD-Ag含量的增加，SD-Ag/PVA水凝胶的抑菌效果增强，而且其对革兰式阴性菌（大肠杆菌）的抑菌效果优于其对革兰式阳性菌（金黄色葡萄球菌）的抑菌效果。Abstract: A series of sulfadiazine Ag(SD-Ag)/polyvinyl alcohol(PVA)hydrogel composites were preparated by e-Beam irradiation combining with freeze-thawing. The influence of preparation process of polyvinyl alcohol (PVA) hydrogel on its properties was investigated. The tensile strength, elongation at break, water absorption, gel content, morphologies of the surfaces and their relationships with the mass fraction of PVA and preparation process were characterized using tensile testing machine, SEM and FT-IR.The mechanical tests show that the tensile strength of PVA hydrogel increases with the mass fraction of PVA(5%-15%). When the mass fraction of PVA is 15%, and the irradiation doses is 25 kGy, the tensile strength of PVA hydrogel is 0.023 MPa, 0.048 MPa, 0.028 MPa and the water absorption is 95%, 45%, 63%, by e-Beam irradiation alone, freeze-thawing after irradiation and irradiation after freeze-thawing, respectively, which indicate that e-Beam irradiation combining with freeze-thawing increases the tensile strength and decreses the water absorption of the PVA hydrogel. The antibacterial activity of SD-Ag/PVA hydrogel was investigated after adding SD-Ag into the PVA hydrogel. The zones of inhibition show that the antibacterial activities can be enhanced with the mass fraction of SD-Ag increasing and that the composites have higher antibacterial activity towards Gram-negative bacteria (E. coli) than Gram-positive bacteria (S.aureus).
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