胶原改性的生物活性玻璃/聚己内酯多孔骨修复材料的制备

罗小刚; 陈晓峰; 李玉莉; 沈德勇; 胡庆; 林才

doi:CNKI:11-1801/TB.20110720.1423.031

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胶原改性的生物活性玻璃/聚己内酯多孔骨修复材料的制备

doi: CNKI:11-1801/TB.20110720.1423.031

罗小刚^1,2,
陈晓峰^1,2,,
李玉莉^1,2,
沈德勇^1,2,
胡庆^1,2,
林才^1,2,3

1.
国家人体组织功能重建工程技术研究中心, 广州 510640;
2.
华南理工大学材料科学与工程学院, 广州 510640;
3.
温州医学院附属第一医院, 温州 325000

基金项目: 国家自然科学基金(51072055; 50830101; 50732003); 浙江省自然科学基金(Y407241)

详细信息

通讯作者:
陈晓峰, 教授, 主要从事骨修复用生物医学材料的结构设计和开发方面的研究 E-mail: chenxf@scut.edu.cn

中图分类号: TB332
计量
- 文章访问数: 1119
- PDF下载量: 776
- 被引次数: 0
出版历程
- 收稿日期: 2010-11-24
- 修回日期: 2011-03-01
- 刊出日期: 2011-12-15

Preparation of collagen modified bioactive glass/poly(ε-caprolactone) porous composites for bone tissue repairing

LUO Xiaogang^1,2,
CHEN Xiaofeng^{1,2
,},
LI Yuli^1,2,
SHEN Deyong^1,2,
HU Qing^1,2,
LIN Cai^1,2,3

1.
National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510640, China;
2.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China;
3.
The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China

摘要

摘要: 结合粒子沥滤-溶剂挥发法, 制备以胶原作为孔壁修饰体的生物活性玻璃(BG)/聚己内酯(PCL)多孔骨修复复合材料。用SEM、FTIR、XRD、等离子体原子发射光谱仪和pH计等对材料的多孔及孔壁形貌、矿化活性、矿化溶液中离子浓度、pH值变化等进行了分析, 采用比重法和称重法研究了胶原对多孔材料的孔隙率和吸水倍率的影响。结果表明: 胶原蛋白成功的黏附到了多孔材料的孔壁, 有效改善了BG/PCL复合材料的亲水性、矿化活性和降解性能, 其孔隙率和吸水倍率分别高达96.400%±0.018%和13.65±1.65。
- 胶原 /
- 生物活性玻璃 /
- 聚己内酯 /
- 修饰 /
- 矿化 /
- 降解
Abstract: Bioactive glass(BG)/poly(ε-caprolactone)(PCL) porous composites modified by collagen for bone repairing were prepared by combining particulates-leaching and solvent-evaporation methods. The morphology of the porous materials and pore-wall, mineralization activity, ionic concentration and variation of pH values were characterized by SEM, FTIR, XRD, plasma atomic emission spectroscope and pH meter. The effects of colllagen on the porosity and water absorption rate were characterized by traditional specific-gravity and weighing methods. The results indicate that collagen can be succesfully adhered onto the pore wall and the mineralization activity and degradability of BG/PCL are effectively improved. Porosity and water absorption rate are as high as 96.400%±0.018% and 13.65±1.65, respectively.
- collagen /
- bioactive glass /
- poly(ε-caprolactone) /
- modified /
- mineralization /
- degradability