磁性金属有机框架复合材料在生物分析中的应用

关桦楠; 彭勃; 薛悦; 吴巧艳; 张悦

doi:10.13801/j.cnki.fhclxb.20210607.002

磁性金属有机框架复合材料在生物分析中的应用

doi: 10.13801/j.cnki.fhclxb.20210607.002

哈尔滨商业大学　食品工程学院，哈尔滨 150028

基金项目: 国家自然科学基金(31871747；31201376；31370649)；黑龙江省自然科学基金(C2016034)；黑龙江省普通本科高等学校青年创新人新才培养计划(UNPYSCT-2016060)；中国博士后基金(2014T70304；2013M531009)；黑龙江省博士后资助项目(LBH-Z13002)；哈尔滨商业大学科研项目(17XN026)；哈尔滨商业大学大学生创新创业训练计划项目(201810240080)

详细信息

通讯作者:
关桦楠，博士，教授，博士生导师，研究方向为食品安全快速检测分析　E-mail：hsdghn@163.com

中图分类号: TS207.3
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- 被引次数: 0
出版历程
- 收稿日期: 2021-04-08
- 修回日期: 2021-05-11
- 录用日期: 2021-05-31
- 网络出版日期: 2021-06-07
- 刊出日期: 2022-04-01

Application of magnetic metal organic framework composites in bioanalysis

College of Food Engineering, Harbin University of Commerce, Harbin 150028, China

摘要

摘要: 金属-有机框架(MOFs)是由金属离子或团簇和有机配体，通过配位键自行组装形成的具有多孔结构的有机-无机杂化材料。由于它们具有框架结构可调、高孔隙率、化学稳定性良好、可再生性和合成过程简单等优点而广泛应用于小分子的吸附分离、催化化学反应、催化降解、富集物质、氧化还原反应等诸多领域。磁性金属有机框架(MMOFs)是在金属有机框架的基础上引进磁性金属粒子，极大地改良并优化了其原有的性能，丰富了金属有机框架的研究内容，拓宽了金属有机框架在食品、农药、生物分析中的应用。本文以磁性金属有机框架为研究对象，对其在生物分析中的应用进行了系统论述，在此基础上总结了当前MMOFs材料在该领域中存在的局限，并对研究新趋向提出了展望。
- 磁性纳米粒子 /
- 金属有机框架 /
- 食品分析 /
- 模拟酶 /
- 富集
Abstract: Metal-organic framework (MOFs) was an organic-inorganic hybrid material with porous structure formed by self-assembly of metal ions or clusters and organic ligands through coordination bonds. They have the advantages of adjustable frame structure, high porosity, good chemical stability, reproducibility and simple synthesis process. Therefore, it was widely used in adsorption and separation of small molecules, catalytic chemical reaction, catalytic degradation, enrichment of substances, REDOX reaction, drug dilution and other fields. Magnetic metal organic framework (MMOFs) introduces magnetic metal particles on the basis of metal organic framework, greatly improves and optimizes its original performance, enriches the research content of metal organic framework, and widens the application of metal organic framework in food, pesticide and biology analysis. In this paper, the application of magnetic metal-organic framework in bioanalysis was systematically discussed. On this basis, the limitations of current MMOFs materials in this field were summarized, and the new trend of research was proposed.
- magnetic nanoparticle /
- metal-organic frameworks /
- food analysis /
- mimetic enzyme /
- enrichmen

HTML全文

图 1 Fe₃O₄-COOH@MIL-101复合物的合成路线及利用Fe₃O₄-COOH@MIL-101复合物快速简便富集细胞裂解物中生物标志物的流程图^[33]

Figure 1. Synthesis route of Fe₃O₄-COOH@MIL-101 composites and the flowchart of fast and convenient enrichment of biomarkers from cell lysates using Fe₃O₄-COOH@MIL-101 composites^[33]

BDC—Phthalic acid; MALDI-TOF MS—Matrix-assisted laser desorption/ionization time of flight mass spectrometry

下载: 全尺寸图片幻灯片

图 2 制备Fe₃O₄@MIL(Fe/Ti)纳米粒子的合成程序示意图 (a) 和使用Fe₃O₄@MIL(Fe/Ti)纳米粒子和磁分离选择性富集磷酸化肽的典型过程 (b)^[36]

Figure 2. Schematic illustration of the synthetic procedure for the preparation of Fe₃O₄@MIL(Fe/Ti) nanoparticles (a) and typical process for selective enrichment of phosphorylated peptides using Fe₃O₄@MIL(Fe/Ti) nanoparticles and magnetic separation (b)^[36]

MAA—Methacrylic acid; TEOS—Tetraethyl orthosilicate

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图 3 米诺环素(MC)在Fe₃O₄@MIL-68(Al)上的吸附机制^[39]

Figure 3. Adsorption mechanisms of minocyline (MC) on Fe₃O₄@MIL-68(Al)^[39]

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图 4 漆酶在Fe₃O₄-NH₂@MIL-101(Cr)上的固定及其在去除2,4-二氯苯酚中的应用^[46]

Figure 4. Laccase immobilization on Fe₃O₄-NH₂@MIL-101(Cr) and the application for the removal of 2,4-dichlorophenol^[46]

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表 1 磁性金属有机框架(MMOFs)材料的应用

Table 1. Application of magnetic metal organic framework (MMOFs) materials

MMOFs	Analytical substance	Limit of detection	Real sample	Analysis method	Ref.
Fe₃O₄@SiO₂/ZIF-8	Bisphenols	10-15 ng·L⁻¹	Water and plastic packaging of food and drinks	MSPE-HPLC	[14]
Fe₃O₄/g-C₃N₄/HKUST-1	Ochratoxin A	5.0-160.0 ng·g⁻¹	Corn	FLD	[15]
Fe₃O₄@MIL-100(Fe)	Non-steroidal anti-inflammatory drugs(NSAIDs)	0.02-0.09 µg·L⁻¹	Water	UPLC-MS/MS	[16]
Fe₃O₄@TMU-8	Cu²⁺	0.3-1 mg·L⁻¹	Tomato	ICP-AES	[17]
M-MOF/β-CD	Prochloraz and triazole fungicides	0.25-1.0 μg·L⁻¹	Tomatoes and lettuce vegetables	HPLC-MS/MS	[42]
Fe₃O₄@PDA@ZIF-8	Endogenous peptide	15 fmol	HSA tryptic digest	MALDI-TOF MS	[52]
Fe₃O₄@A-TpBD@NH₂- MIL-125(Ti)	Endocrine-disrupting chemicals	0.37-0.85 μg·L⁻¹	Milk	HPLC/MS/MS	[53]
MMOF	Ampicillin	0.29 mg/L	Cow milk	UAMSPE-HPLC-UV	[54]
Fe₃O₄-NH₂@MIL-101	Sudan dyes	0.01-25 μg·mL⁻¹	Tomato sauce	HPLC-DAD	[55]
Fe₃O₄@TMU-24	Plasticizer compounds	0.5-250 μg·mL⁻¹	Drinks	GC-FID	[56]
Notes: MSPE-HPLC—Magnetic-solid phase extraction high-performance liquid chromatography; FLD—Fraunhofer line discriminator; UPLC-MS/MS—Ultra performance liquid chromatography tandem mass spectrometry; ICP-AES—Inductively coupled plasma-atomic emission spectrometry; HPLC-MS/MS—High performance liquid chromatography tandem mass spectrometry; HPLC/MS/MS—High performance liquid chromatography/tandem mass spectrometry; UAMSPE-HPLC-UV—Magnetic-solid phase extraction high-performance liquid chromatography-ultra violet; HPLC-DAD—High-performance liquid chromatographydiode array detection; GC-FID—Gas chromatography-flame ionization detector; PDA—Polydopamine; A-TpBD—4-aminobenzoic acid- 1,3,5-triformylphloroglucinol-Benzidine.

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