图  1  透明质酸(HA) (a)、HA-甲基丙烯酸缩水甘油酯(HA-GMA) (b)核磁共振波谱仪图

Figure  1.  ^HNMR spectrometer of hyaluronic acid (HA) (a) and HA-glycidyl methacrylate (GMA) (b)

图  2  双网络水凝胶制备流程图

Figure  2.  Flow chart of double network hydrogel preparation

Fmoc-^DPhe—Fmoc-^Dphenylalanine; LAP—lithium phenyl-2,4,6-trimethylbenzoylphosphinate;

图  5  HA-GMA水凝胶、Fmoc-^DPhe超分子水凝胶和复合水凝胶对罗丹明B的累计释放量曲线

Figure  5.  Release of rhodamine B from the Fmoc-^DPhe hydrogel, HA-GMA hydrogel and composite hydrogel

图  3  Fmoc-^DPhe超分子水凝胶、复合水凝胶及HA-GMA水凝胶的存储模量G’ (a) 和溶胀率 (b)

Figure  3.  Storage modulus G’ (a) and weight swelling ratio (b) of Fmoc-^DPhe hydrogel, HA-GMA hydrogel and composite hydrogel

图  4  分别采用不同的Fmoc-^DPhe (a) 和HA (b) 浓度研究复合水凝胶罗丹明B的释放曲线图

Figure  4.  Release of rhodamine B of composite hydrogel with different concentrations at Fmoc-^DPhe hydrogel (a) and HA-GMA hydrogel (b)

图  9  Fmoc-^DPhe超分子水凝胶((a)、(b))、HA-GMA水凝胶(c)的SEM图像

Figure  9.  SEM images of Fmoc-^DPhe supramolecular hydrogel ((a), (b)) and HA-GMA hydrogel (c)

图  10  Fmoc-^DPhe和HA-GMA复合水凝胶不同放大倍数的SEM图像

Figure  10.  SEM images of Fmoc-^DPhe and HA-GMA composite hydrogel

图  6  Fmoc-^DPhe水凝胶、复合水凝胶及HA-GMA水凝胶对金黄色葡萄球菌的抑制作用

Figure  6.  Antibacterial ring experiment of Fmoc-^DPhe hydrogel, composite hydrogel, HA-GMA hydrogel

PBS—Phosphate buffered saline

图  7  PBS、Fmoc-^DPhe水凝胶、含银离子的Fmoc-^DPhe水凝胶、复合水凝胶及含银离子的复合水凝胶对金黄色葡萄球菌的抑制作用

Figure  7.  Antibacterial ring experiment of PBS, Fmoc-^DPhe hydrogel, Fmoc-^DPhe and Ag⁺ hydrogel, composite hydrogel, composite hydrogel and Ag⁺, respectively

图  8  Fmoc-^DPhe超分子水凝胶、HA-GMA水凝胶及复合水凝胶的CD信号(a)和UV曲线(b)

Figure  8.  CD (a) and UV (b) spectrometer of Fmoc-^DPhe hydrogel, HA-GMA hydrogel and composite hydrogel

图  11  Fmoc-^DPhe水凝胶、HA-GMA水凝胶和复合水凝胶的细胞毒性实验

Figure  11.  Cell viability studies according to the MTT assay in CCC-HSF-1 cells in the presence of Fmoc-^DPhe hydrogel, HA-GMA hydrogel, composite hydrogel