Abstract: Arginine-glycine-aspartic (RGD) peptide was grafted to the surface of apatite-wollastonite (AW) via plasma-aided treatment. The bioactivity of the RGD-AW was investigated by SEM and EDS after immersing in simulated body fluid (SBF). The results show that modifying AW with RGD peptide enhance the HA deposition and in vitro mineralization properties, and the HA shows warm-like appearance. In order to survey the in vitro and in vivo biocompatibility of RGD-AW, MG-63 osteoblast-like cells were employed to co-culture with these two materials and animal test was carried out to evaluate the bone regenerative properties of RGD-AW materials. The fluorescence microscope result shows that RGD-AW improves the cell adhesion and spreading compared with AW. The histological evaluation of RGD-AW shows that the bone regeneration and remodeling process are significantly enhanced compared with the original AW after 2 weeks, 4 weeks and 8 weeks implantation, respectively. And the hematopoietic function reconstruction which is along with the structure remodeling is only observed on RGD-AW composite after 8 weeks implantation.