Abstract: Negative Poisson’s ratio lattice structures are mechanical metamaterials with a periodic microstructure and tunable, controllable mechanical properties. A new three-dimensional reentrant plate-shaped negative Poisson's ratio lattice structures was designed by combining plate-shaped structures with an reentrant hexagonal geometry in this paper (3D-RPLS). Experimental samples were fabricated using 3D printing, and quasi-static mechanical tests were conducted on the base material and negative Poisson's ratio lattice structure. Finite element simulations were performed based on the experiments. The simulations are in good agreement with the experimental results. The effects of impact velocity and geometric parameters on the impact resistance behavior of 3D-RPLS were further systematically studied. A theoretical solution for the plateau stresses under low and high-speed impacts was derived. The theoretical results show good agreement with the finite element simulation results. The research results show that compared to conventional honeycomb structures, the 3D-RPLS demonstrate superior mechanical properties. As the impact velocity increases, the deformation mode of the 3D-RPLS transition from overall reentrant deformation to localized deformation, and eventually to layer-by-layer collapse. Both the plateau stresses and specific energy absorption of the 3D-RPLS show a positive correlation with the impact velocity. The effects of the geometric parameters α, β, and θ on the impact resistance properties of the 3D-RPLS are different. Both plateau stresses and specific energy absorption are positively correlated with β and θ. Plateau stresses are negatively correlated with α. Specific energy absorption increases with α and then decreases.