Abstract: Carbon fiber reinforced resin matrix composites are widely used in the manufacturing of structural components in fields such as aerospace. However, during the curing process of the autoclave forming process, composite materials are prone to wrinkling defects and curing deformation. Wrinkling defects will reduce the strength of the parts, and curing deformation will cause the dimensions of the parts to exceed the tolerance, failing to meet the assembly requirements. Therefore, this paper takes the typical main load-bearing structural component, the C-shaped beam, as the research object, and uses the finite element simulation method to study the interaction relationship between wrinkle defects and curing deformation. At the same time, it studies the influencing factors of curing defects in the C-shaped beam during the forming process and controls the occurrence of wrinkle defects and curing deformation in the autoclave forming process. The research results show that the curing process will have an impact on the evolution of wrinkles, and at the same time, the defect of wrinkles will also reduce the curing deformation. On this basis, the layup sequence and pressure field were optimized and designed to control the occurrence of wrinkle defects.