Abstract: In order to solve the problem of insufficient mechanical properties of W-direction nodes of traditional glued honeycomb cores, a layer-to-layer interlocked honeycomb structure was designed, and carbon fiber monolithic honeycomb fabric was prepared, the composite honeycomb core samples were obtained by the vacuum assisted resin infusion molding technology (VARI). The layer-to-layer interlocked structure of the honeycomb fabric can effectively enhance the connection strength of the core nodes, inhibit the buckling of the honeycomb wall during out-of-face compression and the cracking of the connection wall during node stretching, so as to achieve the purpose of strengthening the mechanical properties of the honeycomb core. Three kinds of honeycomb cores with process parameters were designed, and the influence laws of fiber structure on the out-of- plane compression and nodal tensile properties of honeycomb cores were investigated. The results show that the sample compression strength reaches the maximum value of 49.01 MPa when the weft yarn adopts the parameters of T300-3k and 8 picks/cm, and the sample nodal tensile strength reaches the maximum value of 0.85 MPa when the weft yarn adopts the parameters of T300-1k double hinged strand and 10 picks/cm.