可降解镁基骨植入物腐蚀敏感性的数值模拟与试验评估

Numerical simulation and experimental evaluation of the corrosion susceptibility of degradable magnesium-based bone implants

  • 摘要: 镁基合金作为"第三代生物医用材料",以其优异的生物相容性和可降解性吸引了众多学者的关注。在传统医疗骨植入器械难以降解的背景下,展现出了其独特的潜力。然而,由于植入后在人体体液环境的应力和腐蚀作用下腐蚀损伤和退化速率的未知性,难以预测其在临床应用中的性能。因此,为防止因退化过快而导致过早地断裂失效,本研究建立了一种应用于金属腐蚀性能预测的数值模型,该模型被用于研究镁基合金的腐蚀行为预测。通过体外腐蚀试验评估其对不同程度应力腐蚀的敏感性并校准模型参数。为测试模型的准确性,对骨植入物的腐蚀行为进行了预测。结果表明,该模型可以可靠地预测各种应力条件下植入物的腐蚀损伤、降解率和相关的机械性能退化。因此,应力腐蚀模型作为一种数值模拟工具,具备准确预测腐蚀行为的同时优化植入物的退化速率的潜力。此外,提出的模型程序和方法适用于不同合金成分、多种应用场景接骨板的应力腐蚀预测,有助于实现植入材料退化速率的精确调节。

     

    Abstract: Magnesium-based alloys, as "third-generation biomedical materials", have attracted the attention of many scholars for their excellent biocompatibility and degradability. In the context of traditional medical bone implant devices, which are difficult to degrade, it shows its unique potential. However, it is difficult to predict its performance in clinical applications due to the unknown rate of corrosion damage and degradation under the stress and corrosive effects of the human body fluid environment after implantation. Therefore, in order to prevent premature fracture failure due to excessive degradation, a numerical model applied to the prediction of corrosion performance of metals was developed in this study to investigate the in vitro corrosion behaviour of AZ31B magnesium alloy splints, and the stress-corrosion susceptibility of the splints was assessed by in vitro corrosion tests, and several sets of tests were conducted to obtain data to calibrate the model parameters. The results show that the established model can accurately predict the corrosion damage, degradation rate, and mechanical property damage of implants under different stress loads. Therefore, the stress corrosion model has the potential as a numerical simulation tool to accurately predict corrosion behaviour while optimising the degradation rate of implants. In addition, the procedures and methods of the proposed model are applicable to the stress corrosion prediction of splints with different alloy compositions and mul- tiple application scenarios, which can help to achieve an accurate regulation of the degradation rate of implant materials.

     

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