Abstract: Using an approximate analytical method, the explicit expression of stress concentration factors is derived for an eccentric circular hole in a tension orthotropic finite-width strip. The accuracy of the expression is adequate except some extreme situations. The error estimate is based on a comparison with the results from finite element analysis. When the eccentricity is taken as zero, i.e. for the simplified case of a center circular hole in a tension orthotropic finite-width strip, the deduced expression has good accuracy, as demonstrated by agreement with values from the references and finite element analysis. It is shown that the formulation method and the derived expressions can be used to solve difficult problems of stress concentration factors for anisotropic materials, although they are quite simple.