Abstract: The in vitro bioactivities of PA6 and nano-HA/PA6 were studied in SBF(simulated body fluid). The results show that PA6 was not bioactive in SBF, and Ca-P compound is slowly deposited on the surface of PA6, but it was not HA. Nano-HA/PA6 composite was chemically active in SBF, and dissolution and deposition of Ca, P ions happened during the culture in SBF. The Ca-P precipitate on the surface of HA/PA6 composite surface was carbonated-apatite. Its weight lost by about 2 % every week. This kind of composite could be one of the best potential bioactive materials for load-bearing bones, substitution or as bioengineering material.