Abstract: With the rapid growth of drug-resistant bacteria, organic bacteriostatic agents have been unable to meet the needs of social public health. High-activity composite bacteriostatic agents can not only retain the properties of single components, but also show more excellent antibacterial properties, thus becoming an important research direction of antibacterial materials. In this study, a novel structure Cu₂S@Sodium 3-(benzothiazol-2-ylthio)-1-propanesulfonate (Cu₂S@SBPF) material, Transmission electron microscopy (TEM), X-ray diffraction (XRD), ultraviolet visible spectrophotometer (UV-vis), Fourier transform infrared spectrometer (FT-IR) and X-ray photoelectron spectroscopy analyzer (XPS) were used to characterize the micromorphology, structure and elemental composition of the samples. The antibacterial properties of the composite against Gram-negative bacteria E. coli, Gram-positive bacteria S. aureus and drug-resistant bacteria T-Salmonella were investigated. The results showed that the antibacterial rate of the composite at the concentration of 500 µg/mL to E. coli, S. aureus and T-Salmonella reached 99.99% at 60 min, and the composite was the most sensitive to E. coli. The antibacterial mechanism showed that the composite material could destroy the cell wall of bacteria into the interior of bacteria, inhibit bacterial respiration, and eventually cause bacterial death. This result is expected to provide a new solution to solve the problem of bacterial drug resistance.