纳米羟基磷灰石/壳聚糖-硫酸软骨素复合材料的制备及其性能研究

吕彩霞; 姚子华

纳米羟基磷灰石/壳聚糖-硫酸软骨素复合材料的制备及其性能研究

河北大学化学与环境科学学院, 保定 071002

详细信息

通讯作者:
姚子华, 教授, 主要从事材料的结构与性能表征方面的研究 E-mail: lv_caixia@126.com

中图分类号: TB332
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出版历程
- 收稿日期: 2006-04-02
- 修回日期: 2006-06-20
- 刊出日期: 2007-02-14

Preparation and characterization of nano-hydroxyapatite/ chitosan-chondroitin sulfate composite materials

College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China

More Information

Corresponding author:
YAO Zihua

摘要

摘要: 采用共沉淀方法制备了纳米羟基磷灰石/壳聚糖-硫酸软骨素复合材料, 用XRD、 SEM、 EDS、 TGA及万能材料实验机等对材料性能进行了分析表征, 并观察了材料在模拟体液中培养后表面结构、形态以及体系pH值的变化。结果表明: 纳米羟基磷灰石／壳聚糖-硫酸软骨素复合材料具有良好的力学性能, 对机体微环境影响微小、表面矿化效果好,有良好的生物活性和生物相容性。当羟基磷灰石含量为50%时, 抗压强度为42.3MPa, 该复合材料可满足骨组织修复与替代的要求, 有望成为治疗骨缺损的承力替代物。
- 纳米羟基磷灰石 /
- 壳聚糖 /
- 硫酸软骨素 /
- 共沉淀法 /
- 复合材料
Abstract: Nano-hydroxyapatite/chitosan-chondroitin sulfate composites with different mass ratios were prepared through the co-precipitation method. The properties of these composites were characterized and analyzed by means of XRD, SEM, TGA and Universal Testing Machine. The change of the mineralization surface of the composite, pH and the concentration of system in the simulated body fluid were observed. The results show that the nano-hydroxyapatite/chitosan-chondroitin sulfate composites have small influence on the body microenvironment, a good mineralization effect on the surfaces and an excellent biocompatibility and osteoconduction property. The maximum compressive strength value is 42.3MPa at 50% HA. The n-HA/CS-ChS composite can meet the demand of reparation and substitution of osteo-tissue engineering and will be the load-bearing substitute to treat bone defects.
- nano-hydroxyapatite /
- chitosan /
- chondroitin sulfate /
- co-precipitation method /
- composite