复合明胶涂层对钙磷陶瓷多孔支架的增强作用

刘斌; 林萍华; 郭超; 盛晓波; 储成林; 董寅生

复合明胶涂层对钙磷陶瓷多孔支架的增强作用

1.
东南大学材料科学与工程学院, 南京 211189;
2.
河海大学材料科学与工程系, 南京 210098

基金项目: 江苏省高新技术研究资助项目(BG2001033); 日本板梢子公司海外基金资助项目

详细信息

通讯作者:
董寅生, 教授, 主要从事生物材料的设计和制备工艺研究 E-mail: dongy@seu.edu.cn

中图分类号: TB332
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出版历程
- 收稿日期: 2006-10-29
- 修回日期: 2007-03-29
- 刊出日期: 2007-10-14

Calcium phosphate porous ceramic scaffolds reinforced by composite gelatin coating

1.
School of Materials Science and Engineering, Southeast University, Nanjing 211189, China;
2.
Department of Materials Science and Engineering, Hehai University, Nanjing 210098, China

More Information

Corresponding author:
DONG Yinsheng

摘要

摘要: 采用有机泡沫浸渍工艺制备了高孔隙率的钙磷多孔陶瓷支架, 将多孔陶瓷样品浸于明胶溶液中渗涂得到陶瓷/明胶复合支架; 采用复合明胶涂层的方法对钙磷多孔陶瓷支架进行增强处理, 在不破坏多孔支架孔隙特征的情况下, 成功地在样品的孔壁上复合了明胶涂层。复合明胶涂层提高了样品的压缩强度和压缩模量, 与未涂覆样品相比, 涂敷样品受压时的应变特性发生了明显变化。尤其是渗涂5%明胶溶液的多孔样品, 在保持高孔隙率(82.8%)的条件下其压缩强度和压缩模量分别由原来的1.04MPa 和 0.105GPa增加到5.17MPa和0.325GPa。研究结果表明, 孔壁上复合明胶涂层可以有效地增强多孔陶瓷支架。
- 多孔陶瓷支架 /
- 复合明胶涂层 /
- 压缩强度 /
- 压缩模量 /
- 孔隙率
Abstract: The calcium phosphate porous ceramic scaffolds with high porosity for the bone tissue engineering were fabricated by the foam impregnation technology, and the composite scaffolds composed of ceramic and gelatin were gained by coating the porous ceramic samples with gelatin solution. It was found that gelatin coatings were formed on the pore walls of porous scaffold samples successfully without destroying their porous characteristic, but these coatings improved the compressive strength and compressive modulus of the samples. The scaffolds, coated with gelatin, were characterized by their nonlinear fractural behavior under compressive loading. Especially, the compressive strength value and the compressive modulus value of porous samples coated with 5% gelatin solution were improved from ~1.04MPa and ~0.105GPa to 5.17MPa and 0.325GPa respectively with the high porosity (82.8%) maintained. The results indicate that the gelatin coatings on the surface of pores reinforce the porous ceramic scaffolds effectively.
- porous ceramic scaffold /
- composite gelatin coating /
- compressive strength /
- compressive modulus /
- porosity