Abstract: The actively cooled performance of sandwich panel with cellular materials considering heat transfer factors was analyzed, and the thermal performance indexes of cellular materials with two different heat transfer boundary conditions were derived respectively, then the factors which impact the actively cooled performance were obtained. The relationship between optimal relative density and thermal performance index was analyzed in particular relative thickness, and the hexagon has the best performance. The maximum thermal performance index and optimal relative density increase rapidly with the growth of relative thickness, while they get slowly and reach a peak value when the relative thickness grew over 20. The minimum mass was obtained, and the maximum thermal performance index tends towards a constant value with the increasing minimum mass. The minimum mass decreases with the increasing proportion of heat transfer coefficients in the same maximum thermal performance index. At last, the structure was optimized considering the structural load, and the hexagon has the superior performance to others.