Abstract: The low temperature plasma polymerization was used to introduce carboxyl (—COOH) onto the titanium surface. Fibronectin was immobilized to the surface via —COOH. The surface components were characterized by X-ray photoelectron spectroscopy and Fourier transform infrared reflection spectroscopy. The MG63 cells were seeded on the surface of the modified samples and the pure titanium was used as control. The results indicate that fibronectin is immobilized on the titanium and the modified samples are beneficial for the growth and adherence of the cells. The osteogenic activity of the samples with immobilized fibronectin is better than that of the pure titanium.