Abstract: The mixture ratio between host crystal and curing agent of PU resin is calculated by adopting the particle reaction principle based on the same equivalent weight. The results show that the mixture ratio between host crystal and curing agent of PU resin is 100 ∶20～100 ∶26. By the analysis of DSC cures, viscosity2temperature cures, viscosity-time cures and the gelatin time under 25 ℃, the best mixture ratio of 100 ∶20 is confirmed. In order to test and verify its operational performance, the adhesive strength between the resin and the pipeline wall was simulated nd tested. The results show that the adhesive strength of the resin with mixture ratio of 100 ∶20 is so high that it can meet the requirements of the pipeline lining rehabilitation technology.