Abstract: A macroporous calcium phosphate cement (CPC) scaffold with oriented pore structure was prepared by the unidirectional freeze casting method. Two kinds of poly ( lactic-co-glycolic acid) ( PLGA) with different degradation rates were infiltrated into the CPC scaffold to improve the mechanical strength. The results indicate that the compressive strength of scaffolds is greatly improved via PLGA reinforcement. The compressive strength of 6. 37 MPa ±0. 54 MPa is achieved for the PLGA/CPC scaffold. The PLGA/CPC scaffolds prepared by infiltration with PLGA still possess open oriented pore structure, which would be helpful for bone ingrowth into the implant. The PLGA membrane coat on the pore walls of the CPC scaffold can strengthen the matrix and remedy the defects. PLGA sponges in the scaffold can participate in bearing the external load. These contribute to the high strength and toughness of the composite scaffold.