Abstract: The blanket curve design method is an important method for the structural design of laminates. The existing methods of obtaining blanket curves for laminates through blanket tests are expensive, time-consuming, and costly, which are not conducive to the rapid iterative design of structures. This paper achieves the prediction of the limit load and initial stiffness of open-hole laminates under 66 by using ABAQUS finite element parametric modeling based on experimental data, and then builds the blanket curve model quickly based on the response surface method. This method achieves ply assignment, computations submission, and results acquisition through Python scripting, avoids repetitive operations and enhances analysis efficiency, which can be widely used for the rapid construction of other blanket curve models. For laminates without ±45° plies, the in-plane shear strength is a sensitive parameter, meanwhile the cut stress distribution caused by the missing plies in those direction and two-dimensional Hashin criterion controlling the failure of a single layer, lead to a large error in the calculated results lastly when the actual material strength parameters are used. After correction, the blanket curve model obtained can reflect the strength change caused by the change of different direction ply ratio, and the accuracy is high.