Abstract: A new type of titanium alloy grid/carbon fiber hybrid composite laminates (TGCF) was prepared by replacing traditional titanium alloy sheet with titanium alloy woven grid. TGCF with different curing pressures was prepared using the autoclave process, and its microstructure characteristics were quantitatively analyzed to reveal its interfacial bonding mechanism. Room beam shear tests were conducted and their damage evolution behavior and facture mechanism were researched. In addition, comparative experiments were conducted between TGCF and titanium alloy sheet/carbon fiber hybrid composite laminates (HTCLs). The results indicate that resin infiltration into the titanium alloy grid during the curing process can effectively form a multi interface mechanical interlock, and its flow behavior can be promoted by increasing the curing pressure to improve the interfacial bonding ability. When the curing pressure increases from 0 MPa to 0.6 MPa, the porosity of TGCF decreases from (0.89±0.05)% to (0.18±0.03)%, and the interlaminar shear strength (ILSS) increases by 23.80%. In addition, the multi interface interlocking effect of TGCF can significantly inhibition internal interface slip behavior and improve shear resistance. Under the same curing pressure, TGCF shows a 48.90% increase in ILSS compared to HTCLs.