Abstract: Chitosan (CS) is a natural alkaline polysaccharide with good biocompatibility, biodegradable, non-toxic, antibacterial and other advantages, but CS material has poor mechanical properties and easy hydrolysis in water. Graphene oxide (GO) has a large specific surface area and good biocompatibility, stability, and can be combined with other materials to prepare more excellent properties of composite materials. By combining CS and GO to achieve complementary advantages, chitosan/graphene oxide(CS/GO) composites with excellent mechanical properties, biological activity and biocompatibility can be obtained, CS/GO composites can be prepared into hydrogels, nanoparticles, films, porous materials and other forms, which makes CS/GO composites have good application prospects in environmental protection, food, medical and other fields. In this paper, the research status of CS/GO composites in drug carrier, wound dressing, tissue engineering scaffold, contaminant adsorption, food preservation was reviewed, and the future research direction of CS/GO composites was prospected.