钛表面聚氨酯涂层的生物矿化及其细胞生物学响应

郭志君, 邹琴, 王立军, 周斌, 李玉宝, 张利

郭志君, 邹琴, 王立军, 等. 钛表面聚氨酯涂层的生物矿化及其细胞生物学响应[J]. 复合材料学报, 2014, 31(6): 1612-1617.
引用本文: 郭志君, 邹琴, 王立军, 等. 钛表面聚氨酯涂层的生物矿化及其细胞生物学响应[J]. 复合材料学报, 2014, 31(6): 1612-1617.
GUO Zhijun, ZOU Qin, WANG Lijun, et al. Biomineralization of polyurethane-coated titanium and cell behaviors[J]. Acta Materiae Compositae Sinica, 2014, 31(6): 1612-1617.
Citation: GUO Zhijun, ZOU Qin, WANG Lijun, et al. Biomineralization of polyurethane-coated titanium and cell behaviors[J]. Acta Materiae Compositae Sinica, 2014, 31(6): 1612-1617.

钛表面聚氨酯涂层的生物矿化及其细胞生物学响应

基金项目: 国家重大科学研究计划(2012CB933902)
详细信息
    通讯作者:

    张利, 博士, 副教授, 硕士生导师, 研究方向为生物材料. E-mail:zhangli9111@126.com

  • 中图分类号: TB333

Biomineralization of polyurethane-coated titanium and cell behaviors

  • 摘要: 针对当前钛种植体在临床使用中因界面不匹配导致的种植失败问题,从仿生学角度出发,采用提拉法在钛表面涂覆聚氨酯(PU)高分子涂层,并通过过饱和Ca-P溶液浸泡试验在PU表面原位矿化生成了无机沉积物.采用SEM、EDX、IR、XRD、DSC-TG及接触角测定仪等对矿化后PU表面的理化性能进行了表征和分析,并通过细胞培养试验初步考察了MG63细胞在矿化前后PU表面的增殖及生长情况.结果表明,PU表面矿化物是由纳米片状晶体先聚集堆叠形成团簇状微球,然后微球间互相融合生长而形成的,其成分主要是弱结晶的非化学计量的羟基磷灰石晶体,而且矿化后的PU涂层亲水性更佳,更利于MG63细胞的黏附及增殖.
    Abstract: According to the failure of Ti dental implant due to the interface mismatching in clinic, polyurethane (PU) polymer coating was prepared by pulling Ti from PU solution in order to mimic the function and properties of human periodontal tissue. Then, PU-coated Ti was biomineralized by being immersed into supersaturated Ca-P solution for different periods. The physico-chemical properties of the biomineralized PU were characterized and analyzed by means of SEM, EDX, IR, XRD, DSC-TG and water contact angle testing, and the behaviors of MG63 cells were studied by co-culture test. The results indicate that the deposit on PU is formed by the agglomeration of microspheres made of nano-flake crystals and its main ingredient is proved to be poorly crystallized and non-stoichiometric hydro apatite crystals. Also, the biomineralized PU coating has better biocompatibility than PU coating and is more favor of the proliferation and growth of MG63 cells.
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出版历程
  • 收稿日期:  2013-11-17
  • 修回日期:  2014-01-23
  • 刊出日期:  2014-12-14

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