Preparation and mechanical properties of tricalcium phosphate/calcium alginate composite flat sheet membranes
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摘要: 本文提供了一种制备磷酸三钙/海藻酸钙（TCP/CA）复合平板膜的方法，以提高CA水凝胶的强度，并使其力学性能容易测试。在水溶液中将TCP与海藻酸钠复合，制备了TCP/CA复合平板膜，采用红外光谱和扫描电子显微镜对其进行表征，研究了不同TCP含量的TCP/CA复合平板膜的溶胀性能与复合平板膜在湿态和干态下的力学性能。结果表明：随着TCP含量的增加，TCP/CA复合平板膜在生理盐水中的溶胀率逐渐降低；TCP/CA复合平板膜在干态和湿态下的极限应力值均随着TCP含量的增加呈现先增加后减小的趋势；干态下的极限应力、模量和断裂能要明显大于湿态下的。该TCP/CA复合平板膜制备方法简单、厚度可控、易批量生产，在控制释放和组织工程领域有潜在的应用前景。Abstract: This paper provides a method of preparing tricalcium phosphate/calcium alginate (TCP/CA) composite flat sheet membranes to improve the strength of CA hydrogels, and make it easy to test the mechanical properties. The TCP/CA composite flat sheet membranes were prepared by combining TCP with sodium alginate in aqueous solution. The TCP/CA membranes were characterized by FTIR and SEM. The swelling properties and mechanical properties in wet and dry forms of TCP/CA membranes with different contents of TCP were investigated. The results show that with the increase of TCP, the swelling rate of TCP/CA composite flat sheet membranes decreases in physiological saline and the nominal stress value increases first and then decreases both in dry and wet forms with the increase of TCP content. The nominal stress, modulus and fracture energy are significantly greater in the dry form than in the wet form. This method is easy to get TCP/CA composite flat sheet membranes with different thicknesses and get mass production, which could be used in controlled-release delivery and tissue engineering.
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