Abstract: According to the stacking sequence hypothesis of metal, the corresponding material selection optimization mathematical model of hybrid metal-composite structure was established with the material property and layers number as design variables. Taking the hybrid steel-fiber reinforced composite structure as an example, the structural-acoustic radiation dynamic optimization design with multi-variables and multi-constraints problem was presented. In the end, by introducing genetic algorithm, the optimization problems were solved, and the structural material conversion was achieved. The numerical calculation shows that the vibration and acoustic radiation of the hybrid metal-composite structure can be reduced by using material selection optimization method. The paper provides an effective and feasible method to solve the problem for multi-material distribute optimization.