生物活性玻璃/PLA-PEG-PLA/聚乳酸组织工程支架在SBF溶液中的降解和矿化

葛建华; 王迎军; 陈晓峰; 郑裕东

生物活性玻璃/PLA-PEG-PLA/聚乳酸组织工程支架在SBF溶液中的降解和矿化

1.
山东大学材料科学与工程学院, 济南 250061;
2.
华南理工大学材料科学与工程学院, 广州 510640;
3.
北京科技大学材料科学与工程学院, 北京 100083;
4.
山东大学材料液固结构演变及加工教育部重点实验室, 济南 250061

基金项目: 国家自然科学基金（51072055）

详细信息

通讯作者:
葛建华，博士，讲师，主要从事材料学研究 E-mail：gjh100000@sohu.com

中图分类号: TB332
计量
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- 被引次数: 0
出版历程
- 收稿日期: 2012-11-20
- 修回日期: 2013-07-29
- 刊出日期: 2013-12-15

Degradable performance and bio-mineralization function of bioglass/PLA-PEG-PLA/poly(Lactic acid) tissue engineering scaffold in SBF

1.
School of Materials Science and Engineering, Shandong University, Ji'nan 250061, China;
2.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China;
3.
Materials Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China;
4.
Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), Shandong University, Ji'nan 250061, China

摘要

摘要: 通过测定pH值、质量损失率、SEM、XRD和FTIR，系统研究了生物活性玻璃/聚乳酸-聚乙二醇-聚乳酸嵌段共聚物（PLA-PEG-PLA）/聚乳酸组织工程支架在模拟体液（SBF）中的降解和生物矿化性能。研究结果表明：随着支架在SBF溶液中浸泡时间的延长，SBF的pH值和支架的质量呈下降趋势；生物活性玻璃的存在使pH值升高，而PLA-PEG-PLA嵌段共聚物的存在使pH值降低。XRD、FTIR图谱和SEM图像表明：在SBF中浸泡一定时间后，有无定型或结晶不完善的磷灰石在生物活性玻璃/PLA-PEG-PLA/聚乳酸组织工程支架表面沉积形成，并且PLA-PEG-PLA共聚物降解速度比聚乳酸快；在SBF中浸泡7天后，PLA-PEG-PLA共聚物的含量已经很难通过FTIR检测出来。
- 生物活性玻璃 /
- PLA-PEG-PLA /
- 组织工程支架 /
- 降解 /
- 生物矿化
Abstract: The degradable performance and bio-mineralization function of bioglass/poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) block copolymer (PLA-PEG-PLA)/poly(lactic acid) tissue engineering scaffolds were systematically studied in the simulated body fluid (SBF) by measuring pH value of SBF, the mass loss ratio of the scaffolds and analyzing SEM pictures, XRD and FTIR spectra of scaffolds' surface. The results show that in SBF, the pH value of SBF with tissue engineering scaffolds and the mass of scaffolds decrease with the prolongation of time. At the same time, the present of bioglass makes pH value of SBF increase and the present of PLA-PEG-PLA makes pH value of SBF decrease. SEM pictures, XRD and FTIR spectra show that there appears the deposition of carbonate hydroxyl apatite on the surface of the bioglass/PLA-PEG-PLA/poly(lactic acid) tissue engineering scaffolds, and the degradation rate of PLA-PEG-PLA is quicker than that of PLA in SBF, because the present of PLA-PEG-PLA in the sample immersed in SBF for 7 d could not be detected by FTIR.
- bioglass /
- PLA-PEG-PLA /
- tissue engineering scaffold /
- degradation /
- bio-mineralization