Abstract: Recently,the development and application of polymec composite materials have been considered as an efficient way to improve the biocompatibility Liomaterials.In this paper, the advances of the biomedical polymer-based composite materizls have been reviewed. The biomedical polymers obtained by mining with some inorganic fillers,metals,carbons and the other polymers to enhance the biocompatibility have also been introduced the influence of the microphase separation and domain structure on the blood compatibility of the polymer based composite materials for biomedicine was described.It was well known that the degree of phase segregation,shape and size of domains will affect the blood compatibility.