Abstract: 3D printing can be used as an efficient and precise manufacturing method to prepare various medical materials. In this study, polyether ether ketone (PEEK) composites with contents of 5wt% and 10wt% carbon fibre (CF) were prepared by fused deposition moulding (FDM) 3D printing process to investigate the mechanical and micromotional wear properties of CF/PEEK composites with different contents, under temperature of 37℃ and direct contact dry sliding conditions, and pure PEEK printed by 3D printing was selected as a control group. The micromotion parameters were fixed wear time, displacement amplitude and frequency, and the normal load was changed. The friction (Ft)-displacement amplitude (D) curve and friction coefficient curve were established. The wear morphology and wear mechanism of CF/PEEK composites were investigated by laser confocal microscopy and scanning electron microscopy. The results show that, the three materials with the increase of normal load, the friction coefficient decreases, the wear volume increases; 10 CF/PEEK has better mechanical properties, lower coefficient of friction, under different loads for the micromovement condition for the complete slip; CF/PEEK composites have better micromovement properties, the wear mechanism of the pure PEEK for the abrasive wear and adhesive wear interactions, and the wear mechanism of the CF/PEEK The wear mechanism of CF/PEEK composites is abrasive wear. The above study provides some theoretical basis for the application of 3D printed CF/PEEK composites in the medical field.