Abstract: The problems of composite laminated plate's structural vibration and acoustic radiation under external loading were investigated. The structural-acoustic optimization model of composite structure was presented. The stacking sequence problem of symmetric composite laminate and structural-acoustic radiation optimization were caried out using the genetic algorithm. The example shows that the vibration and acoustic radiation of composite laminated can be reduced by optimizing the stacking sequence parameters, such as layers number, layers thickness and layers angle. The calculation results has validited the optimized method.