卵磷脂改性磁性碳纳米管的制备及生物相容性

Preparation and biocompatibility of phosphatidylcholine modified magnetic carbon nanotubes

  • 摘要: 采用生物活性两亲性分子卵磷脂(PC), 对制备的磁性碳纳米管(Fe3O4/CNTs)进行非共价修饰, 得到了内部为疏水端、外部为带电亲水基团的类膜结构包覆的改性复合材料Fe3O4/CNTs-PC。在溶液中带电基团通过溶剂化作用及亲水作用, 在复合材料表面形成水化层, 提高复合材料的自由水含量。在蛋白质吸附实验与复钙化凝血时间评价中, Fe3O4/CNTs-PC对蛋白质吸附量仅为0.1368 mg/mg, 复钙化凝血时间延长至324 s, 具有很好的生物相容性。

     

    Abstract: A kind of biomimetic amphoteric polymer, phosphatidylcholine (PC), was used as surfactant to produce water soluble and biocompatible magnetic carbon nanotubes (Fe3O4/CNTs), which was prepared by solvothermal method. Fe3O4/CNTs was facilely dispersed in aqueous media by ultrasonication with the help of PC, with the long hydrophobic segment and the hydrophilic group as controls. The biological properties of the PC modified Fe3O4/CNTs (Fe3O4/CNTs-PC) were evaluated using protein adsorption assay and recalcification time. The results indicate that the adsorption capacity of bovine serum albumin (BSA) is 0.1368 mg/mg, and the recalcification time is 324 s. These experimental results suggest that Fe3O4/CNTs-PC has good outstanding biocompatibility.

     

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