羟基磷灰石/液晶复合材料仿生人工骨的制备及性能

沈德勇; 方立明; 陈晓峰; 黄彩霞; 罗小刚; 晏龙昊

羟基磷灰石/液晶复合材料仿生人工骨的制备及性能

沈德勇^1,2,
方立明^1,2,,
陈晓峰^1,2,
黄彩霞³,
罗小刚^1,2,
晏龙昊³

1.
华南理工大学生物医学工程研究院, 广州 510640;
2.
国家人体组织功能重建工程技术研究中心, 广州 510640;
3.
华南理工大学材料科学与工程学院, 广州 510640

基金项目: 国家自然科学基金重点项目(50830101); 国家自然科学基金面上项目(51072055); 教育部高校博士点基金项目(200805611030); 广东高校优秀青年创新人才培育项目(N909024a)

详细信息

通讯作者:
方立明, 博士, 讲师, 主要从事生物医学材料研究 E-mail: lmfang@scut.edu.cn

中图分类号: TB332
计量
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- 被引次数: 0
出版历程
- 收稿日期: 2010-09-19
- 修回日期: 2011-03-03
- 刊出日期: 2011-10-15

Preparation and mechanical properties of bone mimicking hydroxyapatite/liquid crystal polymer composite

1.
Institute of Biomedical Engineering, South China University of Technology, Guangzhou 510640, China;
2.
National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510640, China;
3.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China

摘要

摘要: 通过优化的加工条件制备了羟基磷灰石/热致液晶高分子(HA/Vectra A950)复合材料仿生人工骨, 研究了HA含量对复合材料显微结构和力学性能的影响, 分析了HA与Vectra A950共混后的力学性能以及界面结合问题。研究结果表明: 当HA与Vectra A950的质量比小于10∶100时, 复合材料呈现明显的皮芯结构, 皮层液晶微纤高度取向, HA主要分散在芯部, 其模量和强度达到或超过天然骨的力学性能; 随着HA含量的增加, 皮芯结构逐步减弱并消失, 而缺陷显著增加。当HA与Vectra A950的质量比增加到20∶100, 复合材料的力学性能、尤其是韧性显著降低, 这可能是由于HA颗粒与液晶基体之间的结合较差导致的。为保证复合材料仿生人工骨的生物活性, HA的含量应与天然骨接近。因此, 需对HA和Vectra A950的界面进行改性以提高其结合性能。
- 复合材料 /
- 液晶高分子 /
- 羟基磷灰石 /
- 螺杆挤出 /
- 力学性能
Abstract: Hydroxyapatite/thermotropic liquid crystal polymer (HA/Vectra A950) composites were processed with optimized parameters. When the HA/Vectra A950 mass ratio is less than 10/100, the composite exhibits a core-shell structure. The HA particles are mainly dispersed in the core part, while the skin layer is composed of highly oriented Vectra A950 microfibrils. The tensile modulus and strength of the composite are comparable or even higher than those of natural bone. With the increase of HA content, the core-shell structure disappears gradually, but the defects increase. With the increase of HA/Vectra A950 mass ratio to 20/100, the composite mechanical properties, fracture strain in particular, significantly decrease. This is attributed to the interface adhesion between HA particles and Vectra A950 matrix is poor. To ensure the bioactivity, HA content of the bone mimicking composite needs to be close to that of natural bone. Therefore, the interface of HA/Vectra A950 needs to be modified to improve their adhesion.
- composite /
- liquid crystal polymer /
- hydroxyapatite /
- screw extrusion /
- mechanical property