Abstract: The silane coupling agent was used to modify the inorganic bioactive glass (BG) surface aiming at improving affinity with polymer. BG was prepared by sol-gel method, then 3-aminopropyltriethoxysilane (APTES) was grafted onto BG surface. FTIR, TG and laser particle size analyzer were adopted to characterize BG before and after modification, and the cell biocompatibility of the material was studied preliminarily through cell culture. The results show that stretching vibration attributed to saturated C—H appears in FTIR spectrum of modified BG, and remarkable mass loss resulted from combustion of organic group is observed in DTG curve, which suggest that APTES has been bonded onto BG surface. The MC-3T3 cell proliferation measurement and SEM photos show that the modified BG is in favor of the cell growth and proliferation compared with unmodified BG.