Abstract: The overall heat t ransfer coefficients of the sandwich panels with two-dimensional metal cores were analyzed using the effective medium model’. Based on the multifunctional demand for the effective heat t ransfer performance ata specified pumping power and st ructural stiffness , the thermo-mechanical performance of Kagome cells wasstudied in comparison with the t raditional regular t riangle , square and hexagon cells with low relative density. Thein-plane shear stiffness is taken as a relevant measure of the st ructural utility in the work. The analytic result s indicate that Kagome cells provide not only higher levels of heat dissipation performance but also the most optimum multifunctional performances at a specified st ructural weight by optimizing the relative density and the size of the cells.